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B6;129-Hprttm1(CMV-GFP)Nat/J
Cat. No.: CEMM-07250446
Cre excision of a floxed stop sequence enables CMV-directed expression of nuclear localized (nls) GFP in this Hprt (hypoxanthine guanine phosphoribosyl transferase) knock-in line.
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| Status | Live Mouse Frozen Embryo |
| Age | 4 weeks 12 weeks Customized Age |
| Sex | Male Female |
| GENETICS | |
|---|---|
| Allele Symbol |
Hprttm1(CMV-GFP)Nat
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| Allele Name |
targeted mutation 1
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| Allele Attributes |
Conditional ready (e.g. floxed); No functional change
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| Gene Symbol |
Hprt
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| Gene Name |
hypoxanthine guanine phosphoribosyl transferase
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| Chromosome |
X
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| Expressed Genes |
GFP, Green Fluorescent Protein
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| MGI Accession ID | show more close |
| Site of Expression |
GFP will be expressed in cells where promoters driving Cre recombinase are expressed.
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| Strain of Origin |
(B6.129P2-Hprtb-m3/J x 129S-Gt(ROSA)26Sortm1Sor/J)F1
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| Molecular Note |
A pair of insulator sequences, CMV enhancer/beta-actin promoter, loxP site, 3 stop transcription sites, loxP site, nuclear localized (nls) GFP-6xMyc epitope, rabbit beta-globin 3' UTR, and a pair of insulator sequences were inserted into the gene in the indicated order via targeted recombination.
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| HUSBANDRY | |
|---|---|
| Breeding Considerations |
Homozygous females and hemizygous males are viable and fertile. This allele is subject to X-inactivation in females.
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For Research Use Only.
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