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129S/SvEv-Hcn1tm1Kndl/J
Cat. No.: CEMM-07250660
Common Name: HCN1 flox
The exon encoding the pore region and S6 transmembrane domain of the Hcn1 gene are flanked by loxP sites in this HCN1 strain. Cre-mediated excision of the floxed region creates a knockout allele. This mutant mouse strain may be useful in studies of learning, memory, neurophysiology, and Parkinson's Disease.
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| Status | Live Mouse Frozen Embryo |
| Age | 4 weeks 12 weeks Customized Age |
| Sex | Male Female |
| GENETICS | |
|---|---|
| Allele Symbol |
Hcn1tm1Kndl
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| Allele Name |
targeted mutation 1
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| Allele Attributes |
Conditional ready (e.g. floxed); No functional change
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| Gene Symbol |
Hcn1
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| Gene Name |
hyperpolarization-activated
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| Chromosome |
13
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| MGI Accession ID | show more close |
| Site of Expression |
When combined with a Cre recombinase-expressing strain, Hcn1 will be excised in cells where promoters driving Cre recombinase are expressed.
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| Strain of Origin |
129S/SvEv
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| Molecular Note |
A loxP site was inserted upstream of the pore-S6 domain containing exon. At the same time, a floxed neomycin cassette was introduced downstream. Cells in which transient Cre recombinase expression of properly targeted ES cells resulted in excision of neomycin and retention of the pore-S6 exon flanked by loxP sites were selected.
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| HUSBANDRY | |
|---|---|
| Suggested Controls |
Wild-type from the colony
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| Breeding Considerations |
Floxed homozygotes and heterozygotes are viable and fertile.
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| Breeding Strategy |
Heterozygote x Heterozygote
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For Research Use Only.
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