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B6.129S1-Is(14)2Rdf/J
Cat. No.: CEMM-07250360
These 14qC3-MDR mice carry a floxed region that encompases a region corresponding to a minimal deleted region involved in most common B cell chronic lymphocytic leukemias in humans. They have applications in studies related to tumorigenesis and therapeutic management of chronic lymphocytic leukemia.
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| Status | Live Mouse Frozen Embryo |
| Age | 4 weeks 12 weeks Customized Age |
| Sex | Male Female |
| GENETICS | |
|---|---|
| Allele Symbol |
Is(14)2Rdf
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| Allele Name |
insertion
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| Allele Attributes |
Conditional ready (e.g. floxed); No functional change
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| Gene Symbol |
Is(14)2Rdf
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| Gene Name |
insertion
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| Chromosome |
14
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| MGI Accession ID | show more close |
| Site of Expression |
Cre recombination results in EGFP expression in Cre-expressing tissues.
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| Strain of Origin |
129S1/Sv-Oca2+ Tyr+ Kitl+
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| Molecular Note |
LoxP and FRT sites as well as a PGK promoter and Hygro cassette were place about 5 kb telomeric to the alternative exon 1 of Dleu2 by homologous recombination. The targeting was done in ES cells carrying Is(14)1Rdf. The two constructs are in cis configuration.
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| HUSBANDRY | |
|---|---|
| Suggested Controls |
C57BL/6J
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| Breeding Considerations |
When maintaining a live colony, these mice can be bred as homozygotes.
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For Research Use Only.
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