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B6.129S2-Disc1tm1(DISC1/DISC1FP1, DISC1FP1/DISC1, DISC1)Xzho/J
Cat. No.: CEMM-07250805
Common Name: DISC1-Boymaw
DISC1H mice contain a floxed cassette consisting of the two human fusion genes, DB7 and BD13, followed by an SV40 polyadenylation signal and a human wildtype DISC1 cDNA, inserted downstream of the start codon of the murine Disc1 gene. These mice may be useful when studying schizophrenia and other major psychiatric disorders.
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| Status | Live Mouse Frozen Embryo |
| Age | 4 weeks 12 weeks Customized Age |
| Sex | Male Female |
| GENETICS | |
|---|---|
| Allele Symbol |
Disc1tm1(DISC1/DISC1FP1,DISC1FP1/DISC1,DISC1)Xzho
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| Allele Name |
targeted mutation 1
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| Allele Attributes |
Conditional ready (e.g. floxed); Null/Knockout; Inserted expressed sequence; Humanized sequence
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| Gene Symbol |
Disc1
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| Gene Name |
disrupted in schizophrenia 1
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| Chromosome |
8
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| Expressed Genes |
DISC1, DISC1 scaffold protein, human; DISC1FP1, DISC1 fusion partner 1, human
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| MGI Accession ID | show more close |
| Site of Expression |
Neuronal cells.
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| Strain of Origin |
129S2/SvPasCrl
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| Molecular Note |
A floxed cassette containing two human fusion genes, DISC1/DISC1FP1 (DB7) and DISC1FP1/DISC1 (BD13), connected with an IRES followed by a human DISC1 cDNA capped with a splice acceptor site replaced part of exon 1 downstream of the start site via homologous recombination.
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| HUSBANDRY | |
|---|---|
| Suggested Controls |
C57BL/6J
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| Breeding Considerations |
When maintaining a live colony, homozygous mice may be bred together.
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For Research Use Only.
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