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B6.129(C3)-Ino80tm1.1Jland/J
Cat. No.: CEMM-07250647
Common Name: Ino80 Floxed (Ino80fl)
The Ino80 Floxed (Ino80fl) allele has loxP sites flanking exons 2-4 of the Ino80 gene. Removal of the floxed sequence creates a null allele. These mice may be useful in studying the function of the Ino80 chromatin remodeling complex in regulation of DNA repair, DNA replication and transcription.
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| Status | Live Mouse Frozen Embryo |
| Age | 4 weeks 12 weeks Customized Age |
| Sex | Male Female |
| GENETICS | |
|---|---|
| Allele Symbol |
Ino80tm1.1Jland
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| Allele Name |
targeted mutation 1.1
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| Allele Attributes |
Conditional ready (e.g. floxed); No functional change
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| Gene Symbol |
Ino80
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| Gene Name |
INO80 complex subunit
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| Chromosome |
2
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| MGI Accession ID | show more close |
| Strain of Origin |
(129X1/SvJ x 129S1/Sv)F1-Kitl+
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| Molecular Note |
The targeting vector is designed to have a loxP site upstream of exon 2, and an FRT flanked neo cassette followed by a second loxP site just downstream of exon 4. Flp-mediated recombination removed the FRT flanked neo cassette leaving exons 2 through 4 floxed.
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| HUSBANDRY | |
|---|---|
| Suggested Controls |
C57BL/6J
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| Breeding Considerations |
When maintaining a live colony, heterozygous mice may be bred together, to wildtype mice from the colony or to C57BL/6J inbred mice. Alternatively, homozygous mice may be bred together.
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For Research Use Only.
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