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STOCK Gt(ROSA)26Sortm1(RARA*)Soc/HsvJ
Cat. No.: CEMM-07250760
Common Name: R26RAR403
Expression of a dominant negative RAR403 protein is prevented in these R26RAR403 mice until crossed to a strain expressing Cre recombinase under the control of a promoter of interest. This strain may be useful when studying nervous system development.
Inquiry
| Status | Live Mouse Frozen Embryo |
| Age | 4 weeks 12 weeks Customized Age |
| Sex | Male Female |
| GENETICS | |
|---|---|
| Allele Symbol |
Gt(ROSA)26Sortm1(RARA*)Soc
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| Allele Name |
targeted mutation 1
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| Allele Attributes |
Conditional ready (e.g. floxed); Dominant negative; Inserted expressed sequence; Humanized sequence
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| Gene Symbol |
Gt(ROSA)26Sor
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| Gene Name |
gene trap ROSA 26
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| Chromosome |
6
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| Expressed Genes |
RARA, retinoic acid receptor alpha, human
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| MGI Accession ID | show more close |
| Site of Expression |
When bred to mice that express Cre recombinase under the control of a promoter of interest, the loxP-flanked STOP sequence is removed, and RAR403 is expressed in Cre-expressing cells.
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| Strain of Origin |
Not Specified
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| Molecular Note |
A floxed neo-STOP cassette followed by a dominant negative form of human RARA (RAR403) was inserted into the ROSA locus. Cre mediated removal of the neo-STOP cassette is necessary for expression of RAR403.
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| HUSBANDRY | |
|---|---|
| Breeding Considerations |
When maintaining a live colony, homozygous mice may be bred together.
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| Breeding Strategy |
Homozygote x Homozygote
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For Research Use Only.
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