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FVB.129P2(Cg)-Itgavtm2Hyn/J
Cat. No.: CEMM-07250911
Common Name: αvflox
Exon 4 of the mouse Itgav gene is flanked by loxP sites in these αvflox mice. Cre-mediated excision of the floxed region results in a knock-out allele useful in studies of ulcerative colitis, autoimmunity, vascular development, and cancer.
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| Status | Live Mouse Frozen Embryo |
| Age | 4 weeks 12 weeks Customized Age |
| Sex | Male Female |
| GENETICS | |
|---|---|
| Allele Symbol |
Itgavtm2Hyn
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| Allele Name |
targeted mutation 2
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| Allele Attributes |
Conditional ready (e.g. floxed); No functional change
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| Gene Symbol |
Itgav
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| Gene Name |
integrin alpha V
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| Chromosome |
2
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| MGI Accession ID | show more close |
| Strain of Origin |
129P2/OlaHsd
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| Molecular Note |
A floxed neo cassette was inserted at the 5' start of exon 4 and additional loxP site was inserted downstream of exon 4 to Create a floxed allele. The neo cassette was removed by Cre-mediated recombination (source not specified). Insertion was confirmed by PCR and Southern blot.
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| HUSBANDRY | |
|---|---|
| Suggested Controls |
FVB/NJ Wild-type from the colony
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| Breeding Considerations |
Heterozygous and homozygous floxed mice are viable and fertile.
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| Breeding Strategy |
Heterozygote x Heterozygote
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For Research Use Only.
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