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129-Atmtm2.1Fwa/J
Cat. No.: CEMM-07250449
Common Name: Atmc
These mice possess loxP sites flanking exons 57 and 58 of the ataxia telangiectasia mutated homolog (human), Atm, gene and have applications in studies related to Ataxia-Telangiectasia, DNA double-strand-break repair, and DNA double-strand-break joining processes.
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| Status | Live Mouse Frozen Embryo |
| Age | 4 weeks 12 weeks Customized Age |
| Sex | Male Female |
| GENETICS | |
|---|---|
| Allele Symbol |
Atmtm2.1Fwa
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| Allele Name |
targeted mutation 2.1
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| Allele Attributes |
Conditional ready (e.g. floxed); No functional change
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| Gene Symbol |
Atm
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| Gene Name |
ataxia telangiectasia mutated
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| Chromosome |
9
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| MGI Accession ID | show more close |
| Strain of Origin |
129S6/SvEvTac
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| Molecular Note |
Sequence encoding the core PIKK kinase domain of the protein protein product were floxed by placing a loxP site upstream of exon 57 and floxed neomycin cassette downstream of exon 58. The neomycin cassette was subsequently removed by transient infection of Cre recombinase.
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| HUSBANDRY | |
|---|---|
| Suggested Controls |
129S1/SvImJ
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| Breeding Considerations |
When maintaining a live colony, these mice can be bred as homozygotes.
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| Breeding Strategy |
Homozygote x Homozygote
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For Research Use Only.
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