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Mouse Models
Site-specific recombinase (SSR) system is widely used in genetically modification, especially the generation for conditional KO and inducible KO mouse models. For making it more efficient and easier, mouse models with special functions have been generated, such as tissue-specifically expressing Cre, inducible expressing Cre, Split-Cre, floxed (target gene were flanked by loxP sites) mouse, et al.
For assisting our global customers making better breakthrough in their research areas, Creative Biogene offers various of mouse models based on site-specific recombinase systems.
- Floxed Mouse: Floxed mouse models provide a way to study gene function in a controlled and tissue-specific manner, allowing researchers to investigate the roles of specific genes in development, physiology, and disease.
- Reporter Mouse: Reporter mouse models generated with SSR technology offer a means to visualize and study gene expression patterns in a tissue-specific or cell-specific manner. They are invaluable tools in deciphering the intricacies of developmental processes and disease mechanisms.
- Inducible Mouse: Inducible mouse models generated with SSR technology are genetically engineered mouse strains that allow for controlled and temporal regulation of gene expression in specific tissues or cell types.
- Recombinase-expressing Mouse: Recombinase-expressing mouse models are genetically modified mouse models that express Cre recombinase tissue-specifically or temporal-specifically.
If you couldn't find the mouse models you need or you are seeking for other model animals, please check out our gene engineering service or just feel free to contact us and get started with our trustable one-stop service.
Our Mouse Models
| B6;129-Gabrb3tm2.1Geh/J (Cat. No.: CEMM-07250103) | Inquiry | |
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These Gabrb3 (gamma-aminobutyric acid (GABA-A) receptor, subunit beta 3) conditional (floxed) mutant mice may be useful in generating conditional mutations for studying the role of neurodevelopmental diseases and sensitivity to anesthetics and ethanol.
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| 129S-Top2btm2Jcw/J (Cat. No.: CEMM-07250105) | Inquiry | |
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These Top2βflox2 (topoisomerase (DNA) II beta) mutant mice may be useful in generating conditional mutations for studying neural development.
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| STOCK Epas1tm1Mcs/J (Cat. No.: CEMM-07250106) | Inquiry | |
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Hif-2α 2-loxP contains loxP sites flanking exon 2 of the endothelial PAS domain protein 1. These floxed mutant mice may be useful in generating conditional mutations for studies related to erythropoiesis.
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| B6;129-Eif2ak4tm1.1Dron/J (Cat. No.: CEMM-07250108) | Inquiry | |
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GCN2.KO4conditional (also called GCN2.KO4c) mice have loxP sites flanking exon XII of the eukaryotic translation initiation factor 2 alpha kinase 4 gene (Eif2ak4 or GCN2), and may be useful in generating conditional mutations for studying eIF2 (eukaryotic initiation factor 2) phosphorylation in response to environmental stresses (amino acid starvation, proteasome inhibition and UV irradiation).
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| B6.129P2(SJL)-Myd88tm1Defr/J (Cat. No.: CEMM-07250145) | Inquiry | |
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These Myd88fl mice have loxP sites flanking exon 3 of the myeloid differentiation primary response gene 88 (Myd88). These mutant mice may be useful for Cre-lox studies of signal transduction, Toll-like receptor signaling and natural killer cells.
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| FVB.129S4(B6)-Gt(ROSA)26Sortm1Sor/J (Cat. No.: CEMM-07250159) | Inquiry | |
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These mutant mice may be used as a Cre-reporter strain; to test the tissue/cellular expression pattern of cre transgenic mice. When crossed with a cre transgenic strain, the STOP sequence is removed and lacZ is expressed in cells/tissues where cre is expressed.
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| B6.129S4-Csnk1dtm1Drw/J (Cat. No.: CEMM-07250177) | Inquiry | |
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These Csnk1d (casein kinase 1, delta), CK1deltaflox, mutant mice may be useful in generating conditional mutations for studying circadian rhythm and behavior.
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| B6.129S4-Csnk1etm1Drw/J (Cat. No.: CEMM-07250178) | Inquiry | |
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These Csnk1e (casein kinase 1, epsilon), CK1epsilonflox2-3, mutant mice may be useful in generating conditional mutations for studying circadian rhythm and behavior.
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| B6.129S4-Clocktm1Rep/J (Cat. No.: CEMM-07250179) | Inquiry | |
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These Clock (circadian locomoter output cycles kaput), Clockflox, mutant mice may be useful in generating conditional mutations for studying circadian rhythm and behavior.
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| B6;129P2-Gt(ROSA)26Sortm1(CAG-ALPP)Fawa/J (Cat. No.: CEMM-07250180) | Inquiry | |
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These mice contain (STOP-hPLAP): the human alkaline phosphatase, placental (Regan isozyme), ALPP, gene under the control of the CAG (chicken beta actin promoter/enhancer and cytomegalovirus immediate-early enhancer) promoter, inserted into the Gt(ROSA)26Sor locus. Expression of the ALPP gene is blocked by a loxP-flanked STOP fragment placed between the ALPP sequence and the Gt(ROSA)26Sor promoter. This strain serves as a reporter strain, with successful Cre-mediated excision being indicated by ALPP expression in cre-expressing tissues.
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For Research Use Only.