Products

Online Inquiry

B6.129P2(SJL)-Myd88tm1Defr/J

Cat. No.: CEMM-07250145

Common Name: Myd88fl
These Myd88fl mice have loxP sites flanking exon 3 of the myeloid differentiation primary response gene 88 (Myd88). These mutant mice may be useful for Cre-lox studies of signal transduction, Toll-like receptor signaling and natural killer cells.
Inquiry
Status Live Mouse
Frozen Embryo
Age 4 weeks
12 weeks
Customized Age
Sex Male
Female
GENETICS
Allele Symbol
Myd88tm1Defr
show more close
Allele Name
targeted mutation 1
show more close
Allele Attributes
Conditional ready (e.g. floxed); No functional change
show more close
Gene Symbol
Myd88
show more close
Gene Name
myeloid differentiation primary response gene 88
show more close
Chromosome
9
show more close
MGI Accession ID
3809600
show more close
Strain of Origin
129P2/OlaHsd
show more close
Molecular Note
Exon 3 was flanked by loxP sites by placing a FRT flanked neo-cassette with a 3' loxP site upstream of exon 3 with an additional loxP site being placed downstream of exon 3. Founders were crossed with ACTB-FLPe mice to remove the neo selection cassette. Expression levels of Myd88 were unaffected by loxP insertion. Cre-recombination is predicted to excise exon 3 and Create a null allele.
show more close
HUSBANDRY
Suggested Controls
C57BL/6J
show more close
Breeding Considerations
When maintaining a live colony, these mice can be bred as homozygotes.
show more close
Breeding Strategy
Homozygote x Homozygote
show more close
For Research Use Only.
Related Products