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B6.129S4-Clocktm1Rep/J
Cat. No.: CEMM-07250179
These Clock (circadian locomoter output cycles kaput), Clockflox, mutant mice may be useful in generating conditional mutations for studying circadian rhythm and behavior.
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| Status | Live Mouse Frozen Embryo |
| Age | 4 weeks 12 weeks Customized Age |
| Sex | Male Female |
| GENETICS | |
|---|---|
| Allele Symbol |
Clocktm1Rep
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| Allele Name |
targeted mutation 1
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| Allele Attributes |
Conditional ready (e.g. floxed); No functional change
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| Gene Symbol |
Clock
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| Gene Name |
circadian locomotor output cycles kaput
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| Chromosome |
5
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| MGI Accession ID | show more close |
| Strain of Origin |
129S4/SvJae
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| Molecular Note |
A floxed neo cassette containing neomycin resistance and thymidine kinase genes was inserted upstream of exon 5 and a loxp site was inserted downstream of exon 6. Transient Cre expression in ES cells removed the neo cassette leaving exons 5 and 6 floxed.
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| HUSBANDRY | |
|---|---|
| Suggested Controls |
C57BL/6J
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| Breeding Considerations |
When maintaining a live colony, these mice can be bred as homozygotes.
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For Research Use Only.
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