Online Inquiry
129S-Top2btm2Jcw/J
Cat. No.: CEMM-07250105
These Top2βflox2 (topoisomerase (DNA) II beta) mutant mice may be useful in generating conditional mutations for studying neural development.
Inquiry
| Status | Live Mouse Frozen Embryo |
| Age | 4 weeks 12 weeks Customized Age |
| Sex | Male Female |
| GENETICS | |
|---|---|
| Allele Symbol |
Top2btm2Jcw
show more
close
|
| Allele Name |
targeted mutation 2
show more
close
|
| Allele Attributes |
Conditional ready (e.g. floxed); No functional change
show more
close
|
| Gene Symbol |
Top2b
show more
close
|
| Gene Name |
topoisomerase (DNA) II beta
show more
close
|
| Chromosome |
14
show more
close
|
| MGI Accession ID | show more close |
| Strain of Origin |
129S6/SvEvTac
show more
close
|
| Molecular Note |
A self excising neomycin resistance cassette together with an upstream loxP site was inserted in one intron (4?) and a second loxP site was inserted in the third downstream exon. The presence or absence of the neomycin cassette was assessed by PCR but did not affect selection of mice for breeding since the resistance cassette was contained between the two loxP sites.
show more
close
|
| HUSBANDRY | |
|---|---|
| Suggested Controls |
129S1/SvImJ
show more
close
|
| Breeding Considerations |
When maintaining a live colony, these mice can be bred as homozygotes.
show more
close
|
For Research Use Only.
Related Products