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B6;129P2-Gt(ROSA)26Sortm1(CAG-ALPP)Fawa/J
Cat. No.: CEMM-07250180
These mice contain (STOP-hPLAP): the human alkaline phosphatase, placental (Regan isozyme), ALPP, gene under the control of the CAG (chicken beta actin promoter/enhancer and cytomegalovirus immediate-early enhancer) promoter, inserted into the Gt(ROSA)26Sor locus. Expression of the ALPP gene is blocked by a loxP-flanked STOP fragment placed between the ALPP sequence and the Gt(ROSA)26Sor promoter. This strain serves as a reporter strain, with successful Cre-mediated excision being indicated by ALPP expression in cre-expressing tissues.
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| Status | Live Mouse Frozen Embryo |
| Age | 4 weeks 12 weeks Customized Age |
| Sex | Male Female |
| GENETICS | |
|---|---|
| Allele Symbol |
Gt(ROSA)26Sortm1(CAG-ALPP)Fawa
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| Allele Name |
targeted mutation 1
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| Allele Attributes |
Conditional ready (e.g. floxed); Reporter
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| Gene Symbol |
Gt(ROSA)26Sor
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| Gene Name |
gene trap ROSA 26
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| Chromosome |
6
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| Expressed Genes |
ALPP, alkaline phosphatase, placental, human
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| MGI Accession ID | show more close |
| Strain of Origin |
Not Specified
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| Molecular Note |
The human gene driven by the CAG promoter was cloned downstream of a floxed neo cassette and 4 polyadenylation sequences (STOP signal). Expression of the human gene can only be achieved by Cre-mediated removal of the floxed neo STOP cassette.
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| HUSBANDRY | |
|---|---|
| Breeding Considerations |
When maintaining a live colony, these mice can be bred as homozygotes.
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For Research Use Only.
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