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Mouse Models
Site-specific recombinase (SSR) system is widely used in genetically modification, especially the generation for conditional KO and inducible KO mouse models. For making it more efficient and easier, mouse models with special functions have been generated, such as tissue-specifically expressing Cre, inducible expressing Cre, Split-Cre, floxed (target gene were flanked by loxP sites) mouse, et al.
For assisting our global customers making better breakthrough in their research areas, Creative Biogene offers various of mouse models based on site-specific recombinase systems.
- Floxed Mouse: Floxed mouse models provide a way to study gene function in a controlled and tissue-specific manner, allowing researchers to investigate the roles of specific genes in development, physiology, and disease.
- Reporter Mouse: Reporter mouse models generated with SSR technology offer a means to visualize and study gene expression patterns in a tissue-specific or cell-specific manner. They are invaluable tools in deciphering the intricacies of developmental processes and disease mechanisms.
- Inducible Mouse: Inducible mouse models generated with SSR technology are genetically engineered mouse strains that allow for controlled and temporal regulation of gene expression in specific tissues or cell types.
- Recombinase-expressing Mouse: Recombinase-expressing mouse models are genetically modified mouse models that express Cre recombinase tissue-specifically or temporal-specifically.
If you couldn't find the mouse models you need or you are seeking for other model animals, please check out our gene engineering service or just feel free to contact us and get started with our trustable one-stop service.
Our Mouse Models
| B6.129S4(SJL)-Flcntm1Btt/JdchJ (Cat. No.: CEMM-07250692) | Inquiry | |
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The BHDflox allele (Flcnflox) has loxP sites flanking exons 3-4 of the folliculin gene. Cre recombinase-induced removal of the floxed sequence creates a null allele. These BHDflox mice are useful in studying Birt-Hogg-Dube (BHD) syndrome; a rare cancer disorder caused by Flcn mutations that manifests in lung, kidney and skin, and also exhibits characteristics of ciliopathies.
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| STOCK F3tm1Nmk/J (Cat. No.: CEMM-07250695) | Inquiry | |
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The TFflox floxed allele has loxP sites flanking exon 1 of the coagulation factor III gene (F3; tissue factor [TF], thromboplastin or CD142). Removal of the floxed sequence creates a null allele. These mice may be useful in studying deficiency of the primary activator of the blood coagulation cascade.
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| B6;129S6-Gt(ROSA)26Sortm2(CAG-NuTRAP)Evdr/J (Cat. No.: CEMM-07250767) | Inquiry | |
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The NuTRAP allele (Nuclear tagging and Translating Ribosome Affinity Purification) has a loxP-flanked STOP preventing transcription of three individual components: BirA, BLRP-tagged mCherry/mRANGAP1 and EGFP/L10a. When expressed, the BLRP-tagged mCherry/mRANGAP1 protein is biotinylated by BirA, allowing nuclear membrane-labeling with mCherry and biotin (which enables nuclear isolation by fluorescence- and affinity-based purification). Furthermore, EGFP/L10a fluorescently tags the translating mRNA polysome complex (which enables isolation of RNAs that are actively engaged by ribosomes). Overall, NuTRAP mice are a Cre-inducible tool strain that allows labeling and simultaneous isolation of cell type-specific nuclei and mRNA, and are well-suited for studying epigenomics and transcriptomics from specific cell types within a heterogeneous tissue.
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| B6.Cg-Vgftm4.1Srjs/J (Cat. No.: CEMM-07250816) | Inquiry | |
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The VGFflpflox allele has loxP sites flanking the VGF nerve growth factor inducible coding region. Removal of the floxed sequence creates a null allele. These mice may be useful for generating tissue-specific VGF-deletion for studying neuronal activity, survival and progenitor proliferation, synaptic plasticity (fear and spatial memory), BDNF/TrkB-signaling and regulating energy homeostasis/metabolism.
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| STOCK Pnoctm1.1(cre)Mrbr/J (Cat. No.: CEMM-07250983) | Inquiry | |
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Pnoc-IRES-Cre knock-in mice express a Cre recombinase gene inserted upstream of the stop codon of the prepronociceptin (Pnoc) gene. These mice can be used to identify Pnoc expressing cell populations or study pain sensitivity and reward behavior.
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| B6.Cg-Gnb4tm1.1(cre)Hze/J (Cat. No.: CEMM-07250738) | Inquiry | |
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Gnb4-IRES2-Cre-D knock-in mice are designed to have Cre recombinase expression directed to guanine nucleotide binding protein (G protein) beta 4-expressing cells. Cre recombinase expression and activity largely recapitulates the endogenous Gnb4 gene - it is enriched in claustrum but relatively sparse in nearby structures (endopiriform nucleus and deep insular cortex). These mice may be used to generate conditional mutations for studying gain-or-loss of function and/or fate mapping related to this G protein.
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| B6.Cg-Ntng2tm1.1(cre)Hze/J (Cat. No.: CEMM-07250739) | Inquiry | |
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Ntng2-IRES2-Cre-D knock-in mice are designed to have Cre recombinase expression directed to netrin G2-expressing Cre recombinase expression and activity largely recapitulates the endogenous Ntng2 gene - it is enriched in claustrum but relatively sparse in nearby structures (anterior dorsal nucleus, taenia tecta and endopiriform nucleus). These mice may be used to generate conditional mutations for studying gain-or-loss of function and/or fate mapping related to this netrin G protein, such as axon guidance.
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| B6;129S-Cartpttm1.1(cre)Hze/J (Cat. No.: CEMM-07250671) | Inquiry | |
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Cart-IRES2-Cre-D knock-in mice have Cre recombinase expression directed to CART prepropeptide-expressing cells, without disrupting endogenous Cartpt expression. These mice may be used to generate conditional mutations for studying gain-or-loss of function and/or fate mapping in subgroups of brain tissues (including cortex, cerebral nuclei, hypothalamus and midbrain) in regards to feeding, appetite and stress response, as well as gene regulation by cocaine and other drugs.
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| B6.Cg-Ccn2tm1.1(folA/cre)Hze/J (Cat. No.: CEMM-07250672) | Inquiry | |
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Ctgf-2A-dgCre-D knock-in mice express a trimethoprim-inducible EGFP/Cre fusion gene directed by endogenous connective tissue growth factor promoter/enhancer elements, without disrupting endogenous Ctgf expression. When induced, Cre recombinase activity is restricted to layer 6b of the cortex and in restricted populations within the cortical subplate (e.g., endopiriform nucleus). These mice may be used to generate conditional mutations for studying gain-or-loss of function and/or fate mapping in these subgroups of brain tissues.
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| B6.Cg-Ndnftm1.1(folA/cre)Hze/J (Cat. No.: CEMM-07250673) | Inquiry | |
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Ndnf-IRES2-dgCre-D knock-in mice have Cre recombinase expression directed by endogenous neuron-derived neurotrophic factor promoter/enhancer elements, without disrupting endogenous Ndnf expression. Although designed to be trimethoprim-inducible, the Cre recombinase activity is specific and efficient with or without TMP. These mice may be used to generate conditional mutations for studying gain-or-loss of function and/or fate mapping in subgroups of neuronal populations (cortical layer 1, olfactory areas, hippocampal formation, striatum, midbrain and vascular cells).
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For Research Use Only.