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B6.Cg-Vgftm4.1Srjs/J
Cat. No.: CEMM-07250816
Common Name: Vgfflpflox
The VGFflpflox allele has loxP sites flanking the VGF nerve growth factor inducible coding region. Removal of the floxed sequence creates a null allele. These mice may be useful for generating tissue-specific VGF-deletion for studying neuronal activity, survival and progenitor proliferation, synaptic plasticity (fear and spatial memory), BDNF/TrkB-signaling and regulating energy homeostasis/metabolism.
Inquiry
| Status | Live Mouse Frozen Embryo |
| Age | 4 weeks 12 weeks Customized Age |
| Sex | Male Female |
| GENETICS | |
|---|---|
| Allele Symbol |
Vgftm4.1Srjs
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| Allele Name |
targeted mutation 4.1
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| Allele Attributes |
Conditional ready (e.g. floxed)
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| Gene Symbol |
Vgf
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| Gene Name |
VGF nerve growth factor inducible
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| Chromosome |
5
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| MGI Accession ID | show more close |
| Strain of Origin |
(C57BL/6NTac x 129S6/SvEvTac)F1
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| Molecular Note |
A loxP site was inserted into the 5'UTR. Flp-mediated recombination removed an FRT flanked neomycin resistance cassette with a 3' loxP site inserted into the 3' UTR.
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| HUSBANDRY | |
|---|---|
| Suggested Controls |
C57BL/6J
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| Breeding Considerations |
When maintaining a live colony, heterozygous mice may be bred together, to wildtype mice from the colony or to C57BL/6J inbred mice. Alternatively, homozygous mice may be bred together.
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| Breeding Strategy |
C57BL/6J x Heterozygote; +/+ sibling x Heterozygote; Heterozygote x +/+ sibling; Heterozygote x C57BL/6J
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For Research Use Only.
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