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Mouse Models
Site-specific recombinase (SSR) system is widely used in genetically modification, especially the generation for conditional KO and inducible KO mouse models. For making it more efficient and easier, mouse models with special functions have been generated, such as tissue-specifically expressing Cre, inducible expressing Cre, Split-Cre, floxed (target gene were flanked by loxP sites) mouse, et al.
For assisting our global customers making better breakthrough in their research areas, Creative Biogene offers various of mouse models based on site-specific recombinase systems.
- Floxed Mouse: Floxed mouse models provide a way to study gene function in a controlled and tissue-specific manner, allowing researchers to investigate the roles of specific genes in development, physiology, and disease.
- Reporter Mouse: Reporter mouse models generated with SSR technology offer a means to visualize and study gene expression patterns in a tissue-specific or cell-specific manner. They are invaluable tools in deciphering the intricacies of developmental processes and disease mechanisms.
- Inducible Mouse: Inducible mouse models generated with SSR technology are genetically engineered mouse strains that allow for controlled and temporal regulation of gene expression in specific tissues or cell types.
- Recombinase-expressing Mouse: Recombinase-expressing mouse models are genetically modified mouse models that express Cre recombinase tissue-specifically or temporal-specifically.
If you couldn't find the mouse models you need or you are seeking for other model animals, please check out our gene engineering service or just feel free to contact us and get started with our trustable one-stop service.
Our Mouse Models
| C57BL/6-Tg(Nms-icre)20Ywa/J (Cat. No.: CEMM-07250630) | Inquiry | |
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These Nms-iCre mice express codon-improved Cre recombinase in a subset of Nms-expressing neurons in the suprachiasmatic nucleus and may be useful in studying circadian rhythms and behavior.
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| STOCK Tg(Gsx1-cre)6Wql/J (Cat. No.: CEMM-07250735) | Inquiry | |
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These Gsx1cre transgenic mice express Cre recombinase under the control of the Gsx1 promoter and may be useful for generating conditional mutations for studying gain/loss of function or fate mapping in Gsx1 expressing neurons.
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| STOCK Tg(KRT18-cre/ERT2)23Blpn/J (Cat. No.: CEMM-07250386) | Inquiry | |
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These transgenic mice express a tamoxifen-inducible cre recombinase from the human KRT18, keratin 18, promoter. When induced, cre activity is observed in Merkel cells of the skin and simple epithelia. They may be useful in lineage tracing.
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| STOCK Tg(Kiss1-cre)J2-4Cfe/J (Cat. No.: CEMM-07250499) | Inquiry | |
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This Kiss1-Cre transgenic line expresses Cre recombinase in Kiss1 (kisspeptin) expressing cells and neurons and has applications in studies of the gonadotropic axis regulation and reproductive function.
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| B6N.Cg-Tg(CAG-cre/Esr1*)5Amc/CjDswJ (Cat. No.: CEMM-07250420) | Inquiry | |
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These CAGGCre-ERTM transgenic mice exhibit widespread expression of a tamoxifen-inducible Cre recombinase.
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| C57BL/6N-Tg(Calcrl, cre)4688Nkza/J (Cat. No.: CEMM-07250488) | Inquiry | |
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These mice express Cre recombinase under the control of the murine calcitonin receptor-like (Calcrl) promoter. This strain represents an effective tool for generating mossy cell specific-targeted mutants.
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| C57BL/6N-Tg(Camk2a-HBEGF)BNkza/J (Cat. No.: CEMM-07250489) | Inquiry | |
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fDTR-line-B mice express a conditional diphtheria toxin receptor (DTR) under the transcriptional control of the murine CamKIIα promoter. These mice may be useful for neuronal-specific cell ablation.
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| B6;C3-Tg(CAG-DsRed, -EGFP)5Gae/J (Cat. No.: CEMM-07250121) | Inquiry | |
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These IRG transgenic mice are a double-fluorescent, Cre-reporter strain; with widespread expression of red fluorescence prior to Cre recombinase exposure, and green fluorescence following cre-mediated recombination in a pattern determined by cre expression, and should provide a versatile tool for analyzing complex cellular relationships in a wide variety of tissues.
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| B6N.Cg-Tg(Prnp-TARDBP)96Dwc/J (Cat. No.: CEMM-07250372) | Inquiry | |
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Prp-TDP-43Wild-Type transgenic mice have expression of a myc-tagged, human wildtype TAR DNA binding protein (huTDP-43) directed to brain and spinal cord by the mouse prion protein promoter. Along with mice expressing the ALS-linked Q331K mutation (Prp-TDP-43Q331K-low mice and Prp-TDP-43Q331K [~1.5x] mice), these mice may be useful in studying the neurodegenerative disorder amyotrophic lateral sclerosis (ALS; Lou Gehrig's Disease).
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| B6N.Cg-Tg(Prnp-TARDBP*Q331K)109Dwc/J (Cat. No.: CEMM-07250384) | Inquiry | |
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Prp-TDP-43Q331K-low transgenic line 109 mice have expression of a myc-tagged, human TAR DNA binding protein carrying the ALS-linked Q331K mutation (huTDP-43*Q331K) directed to brain and spinal cord by the mouse prion protein promoter. Along with the moderate huTDP-43*Q331K overexpressing founder line (Prp-TDP-43Q331K [~1.5x] mice;), these Prp-TDP-43Q331K-low transgenic mice may be useful in studying motor dysfunction in the neurodegenerative disorder amyotrophic lateral sclerosis (ALS; Lou Gehrig's Disease).
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For Research Use Only.