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Mouse Models
Site-specific recombinase (SSR) system is widely used in genetically modification, especially the generation for conditional KO and inducible KO mouse models. For making it more efficient and easier, mouse models with special functions have been generated, such as tissue-specifically expressing Cre, inducible expressing Cre, Split-Cre, floxed (target gene were flanked by loxP sites) mouse, et al.
For assisting our global customers making better breakthrough in their research areas, Creative Biogene offers various of mouse models based on site-specific recombinase systems.
- Floxed Mouse: Floxed mouse models provide a way to study gene function in a controlled and tissue-specific manner, allowing researchers to investigate the roles of specific genes in development, physiology, and disease.
- Reporter Mouse: Reporter mouse models generated with SSR technology offer a means to visualize and study gene expression patterns in a tissue-specific or cell-specific manner. They are invaluable tools in deciphering the intricacies of developmental processes and disease mechanisms.
- Inducible Mouse: Inducible mouse models generated with SSR technology are genetically engineered mouse strains that allow for controlled and temporal regulation of gene expression in specific tissues or cell types.
- Recombinase-expressing Mouse: Recombinase-expressing mouse models are genetically modified mouse models that express Cre recombinase tissue-specifically or temporal-specifically.
If you couldn't find the mouse models you need or you are seeking for other model animals, please check out our gene engineering service or just feel free to contact us and get started with our trustable one-stop service.
Our Mouse Models
| STOCK Fzd10tm1.1Nat/J (Cat. No.: CEMM-07250662) | Inquiry | |
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Fzd10 coding region sequences are flanked by loxP sites in this Fzd10-CKO-AP allele. Cre-mediated recombination of the floxed region creates a knockout of the gene and enables expression of the alkaline phosphatase coding region under the control of the Fzd10 promoter.
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| B6;129S6-Gt(ROSA)26Sortm1(TARDBP*M337V/Ypet)Tlbt/J (Cat. No.: CEMM-07250718) | Inquiry | |
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TDP-43M337V BAC allele is a Gt(ROSA)26Sor knock-in of a loxP-flanked, full-length human TARDBP genomic locus with M337V mutation in exon 6 and C-terminal fluorescent tag. Prior to Cre recombinase exposure, TDP-43M337V BAC mice have stable, single-copy, low-level expression of TDP-43M337V-Ypet that recapitulates many of the key features of ALS/FTD (amyotrophic lateral sclerosis [Lou Gehrig's disease] / frontotemporal dementia [frontotemporal lobar degeneration]), including progressive motor deficits in conjunction with neuromuscular junction abnormalities and reduced survival.
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| B6;129-Slc9a6tm1Her/J (Cat. No.: CEMM-07251098) | Inquiry | |
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Slc9a6fl conditional mutant mice possess loxP sites flanking exon 1 of the X-linked Slc9a6 (solute carrier family 9 (sodium/hydrogen exchanger), member 6 or NHE6) gene and may be useful in generating conditional mutations to study the development of amyloid plaques and corticobasal degeneration.
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| B6;129-Hprttm1(CMV-GFP)Nat/J (Cat. No.: CEMM-07250446) | Inquiry | |
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Cre excision of a floxed stop sequence enables CMV-directed expression of nuclear localized (nls) GFP in this Hprt (hypoxanthine guanine phosphoribosyl transferase) knock-in line.
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| B6;129-Hprttm2(CMV-tdTomato)Nat/J (Cat. No.: CEMM-07250447) | Inquiry | |
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This strain is currently unavailable due to replenishing of cryopreserved stocks. Interested customers who register interest will be contacted when the strain is again available Cre excision of a floxed stop sequence enables CMV-directed expression of nuclear localized (nls) tdTomato (tdT) fluorescent protein in this Hprt (hypoxanthine guanine phosphoribosyl transferase) knock-in line.
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| B6.Cg-Agtr2em1(cre)Adk/J (Cat. No.: CEMM-07251076) | Inquiry | |
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AT2R-Cre knock-in mice have the endogenous Agtr2 promoter/enhancer sequences directing expression of Cre recombinase. These mice are a Cre-lox tool allowing Cre recombination in Agtr2-expressing cells/tissues (including neurons GABAergic neurons in the nucleus of the solitary tract), and may be useful in studying hypertension.
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| B6.129-Gt(ROSA)26Sortm3(CAG-EGFP/Dsred2)Luo/J (Cat. No.: CEMM-07250037) | Inquiry | |
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These knock-in mice were developed to utilize the mosaic analysis with double markers (MADM) system that allows simultaneous labeling and gene knockout in clones of somatic cells or isolated single cells in vivo. This strain carries the green fluorescent protein, EGFP (G), and the red fluorescent protein, Dsred2 (R), as markers to be used in conjunction with strains carrying the reciprocal chimeric marker genes (MADM-RG).
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| B6.Cg-Tg(CAG-cre/Esr1*)5Amc/J (Cat. No.: CEMM-07250019) | Inquiry | |
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When these CAGGCre-ERTM mice are bred with mice carrying a floxed target gene, tamoxifen-inducible Cre-mediated recombination results in deletion of the floxed sequences in widespread cells or tissues of the offspring, including developing embryos and cultured cells derived from transgenic mice.
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| STOCK Tg(CAG-cre/Esr1*)5Amc/J (Cat. No.: CEMM-07250017) | Inquiry | |
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These CAGGCre-ERTM mice express a fusion protein consisting of Cre recombinase joined to the ligand-binding domain of a modified mouse estrogen receptor and can be used to generate tamoxifen-induced, Cre-mediated targeted deletions when bred with strains carrying a floxed gene.
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| B6J.129S6(FVB)-Slc17a6tm2(cre)Lowl/MwarJ (Cat. No.: CEMM-07250702) | Inquiry | |
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Vglut2-ires-Cre knock-in mice have Cre recombinase expression directed to excitatory glutamatergic neuron cell bodies, without disrupting endogenous vesicular glutamate transporter 2 expression. These mice may be used to generate conditional mutations for studying gain-or-loss of function and/or fate mapping related to glutamatergic neurons.
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For Research Use Only.