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Mouse Models
Site-specific recombinase (SSR) system is widely used in genetically modification, especially the generation for conditional KO and inducible KO mouse models. For making it more efficient and easier, mouse models with special functions have been generated, such as tissue-specifically expressing Cre, inducible expressing Cre, Split-Cre, floxed (target gene were flanked by loxP sites) mouse, et al.
For assisting our global customers making better breakthrough in their research areas, Creative Biogene offers various of mouse models based on site-specific recombinase systems.
- Floxed Mouse: Floxed mouse models provide a way to study gene function in a controlled and tissue-specific manner, allowing researchers to investigate the roles of specific genes in development, physiology, and disease.
- Reporter Mouse: Reporter mouse models generated with SSR technology offer a means to visualize and study gene expression patterns in a tissue-specific or cell-specific manner. They are invaluable tools in deciphering the intricacies of developmental processes and disease mechanisms.
- Inducible Mouse: Inducible mouse models generated with SSR technology are genetically engineered mouse strains that allow for controlled and temporal regulation of gene expression in specific tissues or cell types.
- Recombinase-expressing Mouse: Recombinase-expressing mouse models are genetically modified mouse models that express Cre recombinase tissue-specifically or temporal-specifically.
If you couldn't find the mouse models you need or you are seeking for other model animals, please check out our gene engineering service or just feel free to contact us and get started with our trustable one-stop service.
Our Mouse Models
| B6;129P2-Or2b4tm5(cre)Mom/MomJ (Cat. No.: CEMM-07250058) | Inquiry | |
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This strain expresses a nuclear localized Cre recombinase in the subset of olfactory sensory neurons that would normally express Or2b4 (formerly Olfr124).
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| B6;129P2-Gt(ROSA)26Sortm1Mom/MomJ (Cat. No.: CEMM-07250059) | Inquiry | |
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This targeted insertion of a loxP-flanked STOP taulacZ cassette into the Gt(ROSA)26Sor locus provides a reporter allele for Cre recombinase expression in which taulacZ is expressed along the axons of neurons in which Cre recombinase has excised the loxP-flanked STOP.
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| B6.Cg-Tg(Thy1-Brainbow1.1)MLich/J (Cat. No.: CEMM-07250080) | Inquiry | |
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These Brainbow 1.1 (founder line M) mice allow mutually exclusive expression of three membrane-targeted fluorescent proteins in astrocytes (including glia) throughout the brain, providing unambiguous delineation of boundaries between adjacent astrocytes in cre recombined cells, and may also be useful in conjunction with other Brainbow strains
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| B6;129-Ncstntm1Sud/J (Cat. No.: CEMM-07250111) | Inquiry | |
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Floxed homozygous mice express intact nicastrin gene. They are viable, fertile, normal in size and do not display any gross physical or behavioral abnormalities. When these mutant mice are bred to mice that express Cre recombinase, resulting offspring will have exon 3 deleted in the cre-expressing tissue(s). These mice are useful to study the role of g-secretase in various tissues in combination with tissue specific cre lines.
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| STOCK Tg(Kcnc2-Cre)K128Stl/LetJ (Cat. No.: CEMM-07250118) | Inquiry | |
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Cre is expressed from the Kcnc2 (potassium voltage gated channel, Shaw-related subfamily, member 2, "Kv3.2") promoter in these transgenic mice. When crossed with a lacZ reporter strain, expression is seen in specific subsets of thalamic nuclei and other locations in the brain.
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| 129S-Gt(ROSA)26Sortm3(CAG-luc)Tyj/J (Cat. No.: CEMM-07250147) | Inquiry | |
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A loxP-flanked puromycin resistance/STOP cassette followed by a fusion of firefly luciferase and synthetic antigen peptide SIYRYYGL were introduced to the Gt(ROSA)26Sor (gene trap ROSA 26, Philippe Soriano) locus. After Cre activity, the recombined locus has high expression of Luciferase-SIY fusion protein. This mutant mouse strain may be useful in studies of immune response to a self-antigen or over-expressed tumor-associated antigen when used in combination with tumor-prone models.
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| STOCK Mir135btm1Mtm/Mmjax (Cat. No.: CEMM-07250256) | Inquiry | |
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These microRNA 135b conditional mutant mice are designed to generate a null allele or a lacZ tagged null allele when combined with Flp or Cre recombinase expressing strains. LacZ expression is observed in embryonic brain and spinal cord. This mutant mouse strain may be useful in studies of microRNA biology.
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| STOCK Gata4tm2(Gata4)Wtp/Mmjax (Cat. No.: CEMM-07250266) | Inquiry | |
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These knock-in mutant mice possess a floxed GATA4 cDNA with a transcriptional stop cassette followed by an alkaline phosphatase cDNA; cre-mediated excision activates AP expression. This mutant mouse strain may be useful in studies of cell lineage tracing in the developing and adult heart.
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| STOCK Mir185tm1Mtm/Mmjax (Cat. No.: CEMM-07250279) | Inquiry | |
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These microRNA 185 conditional mutant mice are designed to generate a null allele or a lacZ tagged null allele when combined with Flp or Cre recombinase expressing strains. LacZ expression is observed in embryonic brain and spinal cord. This mutant mouse strain may be useful in studies of microRNA biology.
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| B6;129S-Gt(ROSA)26Sortm38(CAG-GCaMP3)Hze/J (Cat. No.: CEMM-07250290) | Inquiry | |
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Ai38 mice express the fluorescent calcium indicator protein GCaMP3 after exposure to Cre recombinase. Following subsequent calcium binding (such as neuronal activation), bright EGFP fluorescence is observed.
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For Research Use Only.