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C57BL/6J-Dis3l2em4Jtm/J

Cat. No.: CEMM-07250953

Common Name: Dis3l210fl
Exon 10 of the mouse Dis3l2 (DIS3 like 3'-5' exoribonuclease 2) gene is flanked by loxP sites in these Dis3l210f mice. Cre recombinase-mediated excision of the floxed region results in a knock-out of the protein that mimics the deletion of human DIS3L2 exon 9, the most common mutation observed in Perlman syndrome patients, and also associated with Wilms tumor development.
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Status Live Mouse
Frozen Embryo
Age 4 weeks
12 weeks
Customized Age
Sex Male
Female
GENETICS
Allele Symbol
Dis3l2em4Jtm
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Allele Name
endonuclease-mediated mutation 4
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Allele Attributes
Conditional ready (e.g. floxed)
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Gene Symbol
Dis3l2
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Gene Name
DIS3 like 3'-5' exoribonuclease 2
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Chromosome
1
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MGI Accession ID
6294140
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Strain of Origin
C57BL/6J
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Molecular Note
CRISPR/Cas9 technology inserted loxP sites flanking exon 10. Mouse exon 10 is orthologous to human exon 9, deletion of exon 9 is associated with Perlman syndrome.
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HUSBANDRY
Suggested Controls
C57BL/6J Wild-type from the colony
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Breeding Considerations
Heterozygous and homozygous floxed mice are viable and fertile.
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Breeding Strategy
Heterozygote x Heterozygote
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For Research Use Only.
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