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129S6.Cg-Pex1tm1.1Sjms/Mmjax

Cat. No.: CEMM-07250836

These Pex1-G844D mice on the 129S6 background exhibit phenotypes consistent with several features of the mild form of Zellweger spectrum disorder (ZSD) including: growth retardation and shortened life expectancy. In addition, this Pex1 allele possesses loxP sites for the creation of conditional knock out animals.
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Status Live Mouse
Frozen Embryo
Age 4 weeks
12 weeks
Customized Age
Sex Male
Female
GENETICS
Allele Symbol
Pex1tm1.1Sjms
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Allele Name
targeted mutation 1.1
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Allele Attributes
Conditional ready (e.g. floxed); Humanized sequence
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Gene Symbol
Pex1
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Gene Name
peroxisomal biogenesis factor 1
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Chromosome
5
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MGI Accession ID
5570186
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Strain of Origin
129 x C57BL/6
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Molecular Note
A targeting vector was designed to insert a loxP site into intron 11, a loxP-FRT flanked neomycin cassette into intron 13 and a G844D point mutation into exon 15. The mutation results in a G to A change at nucleotide 2531 altering the corresponding amino acid from glycine to aspartic acid at position 844. FLP-mediated recombination removed the FRT flanked neo cassette.
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HUSBANDRY
Suggested Controls
Wild-type from the colony
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Breeding Considerations
While maintaining a live colony, these mice are bred as heterozygotes. Homozygous males can be used for breeding, however, they are less fertile and produce smaller litters. Mice homozygous for the mutation are growth retarded; approximately 30% of mice will not survive to a year. The Donating Investigator indicates that due to their small size, homozygotes require access to gel nutrition from weaning until 12 weeks of age.
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For Research Use Only.
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