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C57BL/6J-Dis3l2em2Jtm/J

Cat. No.: CEMM-07250954

Common Name: Dis3l211fl
Exon 11 of the mouse Dis3l2 (DIS3 like 3'-5' exoribonuclease 2) gene, orthologous to exon 10 of the human gene, is flanked by loxP sites in these Dis3l211f mice. Cre recombinase-mediated excision of the floxed region results in a knock-out that mimics the deletion of human DIS3L2 exon 10. This strain is useful in studies of Perlman syndrome and Wilms tumors.
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Status Live Mouse
Frozen Embryo
Age 4 weeks
12 weeks
Customized Age
Sex Male
Female
GENETICS
Allele Symbol
Dis3l2em2Jtm
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Allele Name
endonuclease-mediated mutation 2
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Allele Attributes
Conditional ready (e.g. floxed)
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Gene Symbol
Dis3l2
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Gene Name
DIS3 like 3'-5' exoribonuclease 2
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Chromosome
1
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MGI Accession ID
6286050
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Strain of Origin
C57BL/6J
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Molecular Note
CRISPR/Cas9 technology inserted loxP sites flanking exon 11, which encodes highly conserved residues essential for catalytic activity.
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HUSBANDRY
Suggested Controls
C57BL/6J Wild-type from the colony
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Breeding Considerations
Heterozygous and homozygous floxed mice are viable and fertile.
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Breeding Strategy
Heterozygote x Heterozygote
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For Research Use Only.
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