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B6;129-Casp4del Panx1tm1Vshe/J
Cat. No.: CEMM-07250585
Panx1fl/fl floxed mice may be useful for studying role of pannexin 1 channels in central nerve system physiology.
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| Status | Live Mouse Frozen Embryo |
| Age | 4 weeks 12 weeks Customized Age |
| Sex | Male Female |
| GENETICS | |
|---|---|
| Allele Symbol |
Casp4del
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| Allele Name |
deletion
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| Allele Attributes |
Null/Knockout
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| Gene Symbol |
Casp4
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| Gene Name |
caspase 4
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| Chromosome |
9
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| MGI Accession ID | show more close |
| Strain of Origin |
129P3/J and 129S1/SvImJ and 129S2/SvPas and 129S6/SvEvTac and 129X1/SvJ
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| Molecular Note |
RT-PCR confirmed that five 129 substrains (129X1/SvJ, 129S1/SvImJ, 129S2/SvPas, 129S6/SvEvTac and 129P3/J) express a transcript that lacks exon 7 (delta110 isoform). Sequencing identified a 5 bp deletion in exon 7 that results in the fusion of exon 6 and 8, a frame-shift after proline 304 and a stop codon after 5 aberrant amino acids. This deletion is not present in C57BL/6. Western blot analysis confirmed the absence of protein expression in LPS-primed macrophage.
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| HUSBANDRY | |
|---|---|
| Suggested Controls |
C57BL/6J
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| Breeding Considerations |
When maintaining a live colony, homozygotes may be bred together.
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For Research Use Only.
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