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C57BL/6-Gt(ROSA)26Sortm1(CAG-SPAST*C448Y)Baas/J
Cat. No.: CEMM-07250762
Common Name: HSP-SPG4-C448Y
HSP-SPG4-C448Y mice contain cre-inducible human spastin (SPAST) sequence with a C448Y mutation, commonly found in patients with hereditary spastic paraplegia (HSP).
Inquiry
| Status | Live Mouse Frozen Embryo |
| Age | 4 weeks 12 weeks Customized Age |
| Sex | Male Female |
| GENETICS | |
|---|---|
| Allele Symbol |
Gt(ROSA)26Sortm1(CAG-SPAST*C448Y)Baas
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| Allele Name |
targeted mutation 1
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| Allele Attributes |
Conditional ready (e.g. floxed); Inserted expressed sequence; Humanized sequence
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| Gene Symbol |
Gt(ROSA)26Sor
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| Gene Name |
gene trap ROSA 26
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| Chromosome |
6
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| Expressed Genes |
SPAST, spastin, human
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| MGI Accession ID | show more close |
| Strain of Origin |
C57BL/6N
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| Molecular Note |
A CAG-promoter-driven loxP-flanked STOP cassette followed by a human full-length spastin (M1) containing a G to A point mutation at position 1343 in exon 11 within the AAA domain resulting in a cysteine to tyrosine change at amino acid 448 was inserted between exons 1 and 2 of the Gt(ROSA)26Sor locus. The C448Y mutation is located in the second pore loop of the AAA domain of spastin and destroys the microtubule-severing activity of the protein. This mutation is commonly found in patients with hereditary spastic paraplegia.
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| HUSBANDRY | |
|---|---|
| Suggested Controls |
C57BL/6NJ
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| Breeding Considerations |
When maintaining a live colony, homozygous mice may be bred together.
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| Breeding Strategy |
Heterozygote x Heterozygote
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For Research Use Only.
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