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B6;129-Oprk1tm2.1Kff/J
Cat. No.: CEMM-07250775
Common Name: KORlox
Oprk1lox/lox mice possess loxP sites flanking exon 3 of the opioid receptor, kappa 1 (Oprd1) gene. These mice may be useful in studying mood disorders and addiction.
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| Status | Live Mouse Frozen Embryo |
| Age | 4 weeks 12 weeks Customized Age |
| Sex | Male Female |
| GENETICS | |
|---|---|
| Allele Symbol |
Oprk1tm2.1Kff
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| Allele Name |
targeted mutation 2.1
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| Allele Attributes |
Conditional ready (e.g. floxed); No functional change
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| Gene Symbol |
Oprk1
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| Gene Name |
opioid receptor
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| Chromosome |
1
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| MGI Accession ID | show more close |
| Strain of Origin |
129
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| Molecular Note |
The targeting vector is designed to insert a loxP-flanked hygromycin resistance (hygro) cassette upstream of exon 3 and a third loxP site downstream of exon 3. Transient transfection with a Cre expression plasmid removed the loxP-flanked hygromycin cassette leaving exon 3 floxed.
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| HUSBANDRY | |
|---|---|
| Suggested Controls |
B6129SF2/J
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| Breeding Considerations |
When maintaining a live colony, homozygous mice may be bred together.
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| Breeding Strategy |
Homozygote x Homozygote
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For Research Use Only.
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