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B6(SJL)-C1qatm1c(EUCOMM)Wtsi/TennJ
Cat. No.: CEMM-07250850
Common Name: C1qaFL
C1qaFL floxed mice have exon 3 of the complement component 1, q subcomponent, alpha polypeptide (C1qa) gene, floxed, making these mice useful for studying the mechanisms of C1q activation and contribution to human health and disease.
Inquiry
| Status | Live Mouse Frozen Embryo |
| Age | 4 weeks 12 weeks Customized Age |
| Sex | Male Female |
| GENETICS | |
|---|---|
| Allele Symbol |
C1qatm1c(EUCOMM)Wtsi
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| Allele Name |
targeted mutation 1c
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| Allele Attributes |
Conditional ready (e.g. floxed); No functional change
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| Gene Symbol |
C1qa
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| Gene Name |
complement component 1
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| Chromosome |
4
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| MGI Accession ID | show more close |
| Strain of Origin |
C57BL/6N-Atm1Brd
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| Molecular Note |
The L1L2_Bact_P cassette was inserted at a position on Chromosome 4 upstream of exon 3 of the gene. The cassette is composed of an FRT site followed by lacZ sequence and a loxP site. This first loxP site is followed by neomycin resistance gene under the control of the human beta-actin promoter, SV40 polyA, a second FRT site and a second loxP site. A third loxP site was inserted in the 3' untranslated region of exon 3. Flp-mediated recombination removed the FRT flanked lacZ and neo cassette.
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| HUSBANDRY | |
|---|---|
| Suggested Controls |
C57BL/6J
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| Breeding Considerations |
When maintaining a live colony, homozygous mice may be bred together.
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| Breeding Strategy |
Homozygote x Homozygote
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For Research Use Only.
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