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B6J.129S4-Bdnftm3Jae/RujfJ
Cat. No.: CEMM-07250959
Common Name: Bdnf2lox
The coding region of the mouse Bdnf (brain derived neurotrophic factor) is flanked by loxP sites in these Bdnf2lox mice. Cre recombinase-mediated excision of the floxed region results in a knock-out allele. This line has been backcrossed to C57BL/6J for more than 10 generations by the donating laboratory
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| Status | Live Mouse Frozen Embryo |
| Age | 4 weeks 12 weeks Customized Age |
| Sex | Male Female |
| GENETICS | |
|---|---|
| Allele Symbol |
Bdnftm3Jae
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| Allele Name |
targeted mutation 3
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| Allele Attributes |
Conditional ready (e.g. floxed); No functional change
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| Gene Symbol |
Bdnf
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| Gene Name |
brain derived neurotrophic factor
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| Chromosome |
2
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| MGI Accession ID | show more close |
| Strain of Origin |
129S4/SvJae
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| Molecular Note |
A single loxP site was inserted 5' to the only coding exon, and a loxP-flanked hygromycin resistance cassette was inserted 3' to the exon. The hygromycin selection cassette was removed in ES cells by transient Cre expression leaving a single loxP site prior to the production of chimeric mice.
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| HUSBANDRY | |
|---|---|
| Suggested Controls |
C57BL/6J Wild-type from the colony
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| Breeding Considerations |
Heterozygous and homozygous floxed mice are viable and fertile.
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| Breeding Strategy |
Homozygote x Homozygote
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| Coat Color |
The coat color is black.
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For Research Use Only.
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