C57BL/6J-Tg(Neurod1-cre/ERT2)M1Fcal/J

Cat. No.: CEMM-07250580

These mice express Cre-ERT2 under the direction of the murine Neurod1 promoter making them useful for spatial- and temporal-specific recombination in Neurod1-expressing cells during development or adulthood.

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Status	Live Mouse Frozen Embryo
Age	4 weeks 12 weeks Customized Age
Sex	Male Female

GENETICS
Allele Symbol	Tg(Neurod1-cre/ERT2)M1Fcal show more close
Allele Name	transgene insertion M1 show more close
Allele Attributes	Recombinase-expressing; Inducible show more close
Gene Symbol	Tg(Neurod1-cre/ERT2)M1Fcal show more close
Gene Name	transgene insertion M1 show more close
Chromosome	UN show more close
Expressed Genes	cre/ERT2, Cre recombinase and estrogen receptor 1 (human) fusion gene show more close
MGI Accession ID	5582823 show more close
Site of Expression	E13.5 neural tube, eye, olfactory epithelium, cranial ganglia, and dorsal root ganglia. Adult neurogenic niche of the hippocampus and in a subset of mature neurons in the cortex, olfactory bulb, thalamus, hypothalamus, and cerebellum. show more close
Strain of Origin	C57BL/6JOlaHsd show more close
Molecular Note	Bacterial artificial chromosome (BAC) library (Source BioScience) was used to obtain a 160 kb BAC (BMQ-305H2) containing the entire mouse Neurod1 gene. This BAC was modified to replace the coding region with a CreERT2 fusion gene (a Cre recombinase fused to a human estrogen receptor ligand-binding domain) followed by a FRT flanked neomycin (neo) selection cassette. Four lines were generated: L (low expression), M1 (intermediate expression), M2, H (high expression). This is a representative record for all lines. Transgene expression patterns are consistent with endogenous gene expression. show more close

HUSBANDRY
Suggested Controls	C57BL/6J show more close
Breeding Considerations	When maintaining a live colony, homozygous mice may be bred together. show more close

For Research Use Only.