B6.FVB(Cg)-Tg(Mylpf-cre)3Kraj/Mmjax

Cat. No.: CEMM-07250696

These CRE3 transgenic mice express Cre recombinase under the control of the rat myosin light chain II ventricular (Mylpf or MLC2v) promoter beginning at E11.5 in the brain. This strain may be useful for generating conditional deletions in neurons and their progenitors.

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Status	Live Mouse Frozen Embryo
Age	4 weeks 12 weeks Customized Age
Sex	Male Female

GENETICS
Allele Symbol	Tg(Mylpf-cre)3Kraj show more close
Allele Name	transgene insertion 3 show more close
Allele Attributes	Recombinase-expressing show more close
Gene Symbol	Tg(Mylpf-cre)3Kraj show more close
Gene Name	transgene insertion 3 show more close
Chromosome	UN show more close
Expressed Genes	Cre, Cre recombinase, bacteriophage P1 show more close
MGI Accession ID	3761931 show more close
Site of Expression	Cre recombinase is expressed in neurons in the brain. show more close
Strain of Origin	FVB/N show more close
Molecular Note	A 250-bp fragment of the rat ventricular light chain II gene (Mylpf) was used as promoter to drive expression of the Cre recombinase cDNA. Crosses of these mice were made to mice (dh4) carrying a transgenic reporter gene (a dominant-hygR gene separated from a constitutive PGK promoter by a loxP-flanked PGK-neo cassette; Cre recombination results in generation of the active-hygR allele detected by PCR). Line 3 was determined to express Cre selectively in the brain. show more close

HUSBANDRY
Suggested Controls	C57BL/6J show more close
Breeding Considerations	While maintaining a live colony, these mice are bred as hemizygotes or homozygotes. show more close

For Research Use Only.