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B6.129S6(Cg)-Ntrk2tm3.1(cre/ERT2)Ddg/J
Cat. No.: CEMM-07250631
Common Name: TrkBCreER
These TrkBCreER mutant mice express Cre-ERT2 from the mouse Ntrk2 promoter. Endogenous NTRK2 expression is knocked out. Treatment with 4-hydroxytamoxifen (OHT) enables the Cre-mediated excision of introduced floxed sequences in dorsal root ganglion neurons.
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| Status | Live Mouse Frozen Embryo |
| Age | 4 weeks 12 weeks Customized Age |
| Sex | Male Female |
| GENETICS | |
|---|---|
| Allele Symbol |
Ntrk2tm3.1(cre/ERT2)Ddg
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| Allele Name |
targeted mutation 3.1
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| Allele Attributes |
Recombinase-expressing; Inducible
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| Gene Symbol |
Ntrk2
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| Gene Name |
neurotrophic tyrosine kinase
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| Chromosome |
13
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| Expressed Genes |
cre/ERT2, Cre recombinase and estrogen receptor 1 (human) fusion gene
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| MGI Accession ID | show more close |
| Site of Expression |
Cre-ERT2 fusion protein is expressed Ntrk2-expressing cells in dorsal root ganglion neurons.
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| Strain of Origin |
129S6/SvEvTac
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| Molecular Note |
A Cre recombinase-estrogen receptor T2 (CreERT2) fusion-FRT Neomycin-FRT loxP cassette was introduced into the first coding ATG of exon 2. All 212 bp of exon 2 (encoding the first 70 amino acids containing entire signal peptide) were replaced.
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| HUSBANDRY | |
|---|---|
| Suggested Controls |
C57BL/6J Wild-type from the colony
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| Breeding Considerations |
Heterozygotes are viable and fertile. Homozygotes die at birth.
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For Research Use Only.
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