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B6.Cg-Gt(ROSA)26Sortm1(CAG-GFP/Eif2c2)Zjh/J
Cat. No.: CEMM-07250357
Common Name: R26-LSL-tAGO2
R26-LSL-tAGO2 mice are used in the miRAP (miRNA tagging and Affinity Purification) method in conjunction with Cre recombinase expressing mice, for genetically targeted microRNA tagging and generating tissue specific miRNA expression profiles.
Inquiry
| Status | Live Mouse Frozen Embryo |
| Age | 4 weeks 12 weeks Customized Age |
| Sex | Male Female |
| GENETICS | |
|---|---|
| Allele Symbol |
Gt(ROSA)26Sortm1(CAG-GFP/Eif2c2)Zjh
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| Allele Name |
targeted mutation 1
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| Allele Attributes |
Conditional ready (e.g. floxed); Reporter; Inserted expressed sequence
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| Gene Symbol |
Gt(ROSA)26Sor
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| Gene Name |
gene trap ROSA 26
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| Chromosome |
6
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| Expressed Genes |
GFP, Green Fluorescent Protein; Ago2, argonaute RISC catalytic subunit 2, mouse, laboratory; myc tag
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| MGI Accession ID | show more close |
| Site of Expression |
When bred to mice that express Cre recombinase, EGFP will be expressed in tissues where promoters driving Cre recombinase are expressed.
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| Strain of Origin |
B6.Cg-Thy1a
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| Molecular Note |
A targeting vector containing loxP site flanked STOP cassette, GFP, and myc-tagged Eif2c2 coding sequence under the control of the CAG promoter was inserted in the Gt(ROSA)26Sor locus. When in the presence of Cre recombinase activity, the GFP/myc tagged Eif2c2 gene is expressed, GFP expression indicates expression of Eif2c2, and the myc epitope tag allowing affinity purification of associated miRNAs.
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| HUSBANDRY | |
|---|---|
| Suggested Controls |
C57BL/6J
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| Breeding Considerations |
When maintaining a live colony, these mice can be bred as homozygotes.
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For Research Use Only.
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