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B6.129S4-Gt(ROSA)26Sortm1(CAG-TMEM192)Dmsa/J
Cat. No.: CEMM-07251017
Common Name: conditional LysoTag (Rosa26; lox-STOP-lox-Tmem192-3xHA)
LysoTag (Rosa26; lox-stop-lox-Tmem192-3xHA) mice conditionally express human TMEM192 cDNA fused to a hemagglutinin (3xHA) tag upon Cre recombinase-mediated excision of a loxP-flanked STOP cassette. Expression of the HA tag enables rapid, tissue-specific, anti-HA antibody-driven immunoisolation of intact lysosomes for content profiling.
Inquiry
| Status | Live Mouse Frozen Embryo |
| Age | 4 weeks 12 weeks Customized Age |
| Sex | Male Female |
| GENETICS | |
|---|---|
| Allele Symbol |
Gt(ROSA)26Sortm1(CAG-TMEM192)Dmsa
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| Allele Name |
targeted mutation 1
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| Allele Attributes |
Conditional ready (e.g. floxed); Inserted expressed sequence; Humanized sequence; Epitope tag
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| Gene Symbol |
Gt(ROSA)26Sor
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| Gene Name |
gene trap ROSA 26
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| Chromosome |
6
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| MGI Accession ID | show more close |
| Strain of Origin |
129S4/SvJae
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| Molecular Note |
A CAG-loxP-neomycin-Stop-loxP-FRT TMEM192-3xHA-FRT pA cassette incorporating full-length human TMEM192 cDNA coding sequences fused to a 3x hemagglutinin tag was introduced to intron 1.
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| HUSBANDRY | |
|---|---|
| Suggested Controls |
C57BL/6J
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| Breeding Considerations |
Heterozygotes and homozygotes are viable and fertile.
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| Breeding Strategy |
Homozygote x Homozygote
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For Research Use Only.
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