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B6.129P2(SJL)-Ntrk3tm1Ddg/J
Cat. No.: CEMM-07250472
These mice carry a hypomorphic floxed F617A mutation in mouse Ntrk3 (neurotrophic tyrosine kinase, receptor, type 3; also called TrkC). Signaling is effectively blocked by application of 1NMPP1. This strain is useful in studies of nerve growth and survival.
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| Status | Live Mouse Frozen Embryo |
| Age | 4 weeks 12 weeks Customized Age |
| Sex | Male Female |
| GENETICS | |
|---|---|
| Allele Symbol |
Ntrk3tm1Ddg
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| Allele Name |
targeted mutation 1
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| Allele Attributes |
Not Specified
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| Gene Symbol |
Ntrk3
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| Gene Name |
neurotrophic tyrosine kinase
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| Chromosome |
7
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| MGI Accession ID | show more close |
| Strain of Origin |
129P2/OlaHsd
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| Molecular Note |
A phenylalanine to alanine substitution mutation at residue 617 (F617A) was introduced via homologous recombination using a mutagenized construct with an FRT flanked neomycin resistance tag. Heterozygotes were bred with mice bearing Tg(ACTFLPe)9205Dym which expressed FLP1 recombinase. The resulting allele has the F617A mutation but the neomycin resistance cassette has been excised.
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| HUSBANDRY | |
|---|---|
| Suggested Controls |
C57BL/6J Wild-type from the colony
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| Breeding Considerations |
Heterozygotes are viable and fertile, but homozygotes reportedly do not breed well.
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| Breeding Strategy |
Heterozygote x Heterozygote
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For Research Use Only.
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