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B6.129P2(129S4)-Hprttm16(Ple167-EGFP/cre)Ems/Mmjax
Cat. No.: CEMM-07250156
These mice have the Ple167-EGFP/NLS-cre transgene targeted as a single copy "knock-in" into the upstream region of the Hprt locus on the X chromosome. The promoter/regulatory regions of the human POGZ gene directs expression of an enhanced green fluorescent protein/Cre recombinase fusion protein.
Inquiry
| Status | Live Mouse Frozen Embryo |
| Age | 4 weeks 12 weeks Customized Age |
| Sex | Male Female |
| GENETICS | |
|---|---|
| Allele Symbol |
Hprttm16(Ple167-EGFP/cre)Ems
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| Allele Name |
targeted mutation 16
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| Allele Attributes |
Recombinase-expressing; Reporter
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| Gene Symbol |
Hprt
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| Gene Name |
hypoxanthine guanine phosphoribosyl transferase
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| Chromosome |
X
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| Expressed Genes |
Cre, Cre recombinase, bacteriophage P1
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| MGI Accession ID | show more close |
| Site of Expression |
Brain
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| Strain of Origin |
129P2/OlaHsd
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| Molecular Note |
The Ple167-EGFP/Cre transgene (pEMS1091) was designed with the 1200 bp Ple167 minipromoter (POGZ-A; derived from a portion of the promoter of the POGZ gene from the Pogo transposable element with ZNF domain (POGZ) gene) upstream of a minimal F5 mutant-FRT site, an EGFP/Cre fusion protein (enhanced green fluorescent protein (with mutated stop) and Cre recombinase), a nuclear localization signal, a second minimal FRT site, an SV40 early polyA signal, and a human HPRT complementary sequence (containing exon1, intron1, exon2, and part of intron2). This construct was targeted as a single copy knockin to the Hprtb-m3 mutant locus on the X chromosome.
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| HUSBANDRY | |
|---|---|
| Breeding Considerations |
The donating investigator recommends maintaining this strain by breeding heterozygous females with C57BL/6J inbred males.
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For Research Use Only.
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