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STOCK Thtm1.1(cre/ERT2)Ddg/J
Cat. No.: CEMM-07250568
Common Name: TH-2A-CreER
These mice express tamoxifen-inducible cre recombinase (cre/ERT2) under the regulatory control of the mouse Th (tyrosine hydroxylase) gene.
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| Status | Live Mouse Frozen Embryo |
| Age | 4 weeks 12 weeks Customized Age |
| Sex | Male Female |
| GENETICS | |
|---|---|
| Allele Symbol |
Thtm1.1(cre/ERT2)Ddg
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| Allele Name |
targeted mutation 1.1
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| Allele Attributes |
Recombinase-expressing; Inducible
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| Gene Symbol |
Th
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| Gene Name |
tyrosine hydroxylase
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| Chromosome |
7
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| Expressed Genes |
cre/ERT2, Cre recombinase and estrogen receptor 1 (human) fusion gene
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| MGI Accession ID | show more close |
| Site of Expression |
When crossed with a strain bearing a loxP-flanked sequence of interest, induced excision of the floxed region by Cre is consistent with the expression of Th in the symphathetic ganglia, dorsal root ganglia and retina.
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| Strain of Origin |
129S6/SvEvTac
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| Molecular Note |
A T2A cleavage peptide and the Cre/ERT2 fusion protein-coding sequence were introduced to the 3'UTR of the mouse Th gene. An FRT PGK-EM7-NEOpolyA-FRT loxP cassette was placed downstream of the 3'UTR region. Homologous recombination was achieved in 129S6/SvEvTac-derived embryonic stem cells and resultant chimeric mice were crossed with Flp mice to excise the neomycin cassette.
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| HUSBANDRY | |
|---|---|
| Suggested Controls |
Wild-type from the colony
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| Breeding Considerations |
Heterozygotes and homozygotes are viable and fertile.
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| Breeding Strategy |
Wild-type x Heterozygote; Heterozygote x Wild-type
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For Research Use Only.
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