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B6;129-Igs1tm7(CAG-Bgeo, -Wnt11)Nat/J
Cat. No.: CEMM-07250394
This Igs1 (intergenic site 1, formerly Ubb) knock-in strain gives constitutive expression of a nuclear localized beta-galactosidase/neomycin resistance protein reporter (NLS-beta-geo) in the absence of cre-mediated recombination. Following cre-mediated recombination, the NLS-beta-geo coding region is excised and Wnt11 is expressed.
Inquiry
| Status | Live Mouse Frozen Embryo |
| Age | 4 weeks 12 weeks Customized Age |
| Sex | Male Female |
| GENETICS | |
|---|---|
| Allele Symbol |
Igs1tm7(CAG-Bgeo,-Wnt11)Nat
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| Allele Name |
targeted mutation 7
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| Allele Attributes |
Conditional ready (e.g. floxed); Inserted expressed sequence; No functional change
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| Gene Symbol |
Igs1
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| Gene Name |
intergenic site 1
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| Chromosome |
11
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| Expressed Genes |
Bgeo, fusion of beta-galactosidase and neomycin phosphotransferase genes, E. coli
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| MGI Accession ID | show more close |
| Site of Expression |
Following Cre-mediated recombination, the NLS-beta-geo coding region is excised and the downstream Wnt11 is expressed. The Wnt11 gene may play roles in the development of skeleton, kidney, and lung..
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| Strain of Origin |
129
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| Molecular Note |
The following elements were inserted, in order, 2 kb 5' of the Ubb gene by targeted recombination in 129-derived embryonic stem (ES) cells: CMV enhancer/beta-actin promoter (CAG), loxP site, beta-geo, 3 stop transcription sites, loxP site, Wnt11, rabbit beta-globin 3' UTR.
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| HUSBANDRY | |
|---|---|
| Breeding Considerations |
Heterozygotes are viable and fertile, but homozygotes are unhealthy.
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For Research Use Only.
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