Online Inquiry
Tissue-specific KO Service
Tissue-specific knockout (KO) mouse is a genetically engineered mouse model in which a specific gene is inactivated or deleted in a specific tissue or cell type. This allows researchers to study the function of a gene in a particular tissue or organ, without affecting other tissues or the entire organism. Creative Biogene offers tissue-specific KO mouse to our global customers for
Introduction into Tissue-specific KO
The process of generating a tissue-specific KO models is similar to that of a conditional KO mouse. In tissue-specific KO mice, the gene of interest is completely deleted, rather than being flanked by specific sites. The deletion is achieved by using a tissue-specific promoter to drive the expression of the recombinase enzyme, which recognizes and removes the gene of interest specifically in the targeted tissue.
Tissue-specific KO model have been used to study the function of genes in a wide range of tissues and organs, including the liver, pancreas, brain, and heart. For example, tissue-specific KO model have been used to study the role of genes in insulin secretion and glucose metabolism in the pancreas, the development of neural circuits in the brain, and the regulation of lipid metabolism in the liver.
Applications of Tissue-specific KO
Tissue-specific knockout (KO) mouse models have a wide range of applications in biomedical research. Here are some examples of their applications:
- Gene function and disease research: Tissue-specific KO models can be used to study the function of specific genes in various tissues and cell types, as well as their roles in the development and progression of various diseases. These models are particularly useful for studying diseases that affect specific tissues or organs, such as heart disease, cancer, and neurodegenerative disorders.
- Drug discovery: Tissue-specific KO models can be used to test the efficacy and safety of new drugs targeted at specific tissues or cell types. These models are particularly useful for developing drugs for diseases that affect specific tissues or organs, such as liver disease, lung disease, and kidney disease.
- Developmental biology: Tissue-specific KO models can be used to study the role of specific genes in embryonic development and organogenesis. By selectively inactivating genes in specific tissues or cell types during development, researchers can better understand the function of these genes in normal development and disease.
- Molecular genetics: Tissue-specific KO models can be used to study the regulation of gene expression in specific tissues and cell types. By selectively inactivating genes in specific tissues or cell types, researchers can better understand the molecular mechanisms that control gene expression.
Tissue-specific KO models provide a powerful tool for investigating the function of genes in a specific tissue or organ, and can help to provide insights into the complex molecular mechanisms that underlie normal physiology and disease.
Our Service
Creative Biogene offers high-quality tissue-specific KO mouse by using tissue-specific promoter and site-specific recombinase system. We provide tissue-specific KO services in species included but not limited as follows.
Why Choose Us
One-stop Service
High-efficiency
Professional Team
High-quality
Creative Biogene has years of experience in site-specific recombinase-based applications. We have established the advanced CreEditTM platform, which aims to support our global customers with high-quality, cost-effective and high-precision one-stop services. Our services are not limited in what we mentioned above, please feel free to contact us and get started with our first-class services.