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STOCK Tg(CAG-Fgfr3*K650E, -EGFP)10Jheb/J
Cat. No.: CEMM-07250867
Common Name: CAG-flox-STOP-flox- FGFR3TDII
FGFR3-GOF mice conditionally express a mouse Fgfr3 (fibroblast growth factor receptor 3) altered to become constitutively active and an EGFP from the CAG promoter. This mutant mouse strain may be useful in studies related to astrocyte activation and other systems involving fibroblast growth factor signaling.
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| Status | Live Mouse Frozen Embryo |
| Age | 4 weeks 12 weeks Customized Age |
| Sex | Male Female |
| GENETICS | |
|---|---|
| Allele Symbol |
Tg(CAG-Fgfr3*K650E,-EGFP)10Jheb
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| Allele Name |
transgene insertion 10
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| Allele Attributes |
Conditional ready (e.g. floxed); Reporter; Inserted expressed sequence
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| Gene Symbol |
Tg(CAG-Fgfr3*K650E,-EGFP)10Jheb
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| Gene Name |
transgene insertion 10
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| Chromosome |
UN
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| Expressed Genes |
GFP, Green Fluorescent Protein; Fgfr3, fibroblast growth factor receptor 3, mouse, laboratory
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| MGI Accession ID | show more close |
| Site of Expression |
Neocortex astrocytes.
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| Strain of Origin |
FVB/N
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| Molecular Note |
The transgenic construct was designed with a CMV-IE enhancer/chicken beta-actin/rabbit beta-globin hybrid promoter (CAG), a loxP-flanked STOP cassette, the mouse Fgfr3 (fibroblast growth factor receptor 3) cDNA containing a lysine to glutamic acid substitution at residue 650 (K650E) rendering Fgfr3 constitutively active, followed by an IRES-eGFP fluorescent protein sequence.
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| HUSBANDRY | |
|---|---|
| Breeding Considerations |
While maintaining a live colony, these mice are bred as hemizygotes. The donating investigator has not attempted to generate homozygous mice.
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| Breeding Strategy |
Hemizygote x Noncarrier; Noncarrier x Hemizygote
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For Research Use Only.
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