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STOCK Rai1tm3Luo/J
Cat. No.: CEMM-07250933
Common Name: Rai1STOP
Rai1STOP mice carry a conditional knock-out allele of the mouse retinoic acid induced 1 (Rai1) gene that is useful in studies of Smith-Magenis syndrome (SMS), a syndromic autism spectrum disorder. Cre recombinase-mediated excision of a loxP-flanked Stop cassette enables tissue-specific expression of the gene.
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| Status | Live Mouse Frozen Embryo |
| Age | 4 weeks 12 weeks Customized Age |
| Sex | Male Female |
| GENETICS | |
|---|---|
| Allele Symbol |
Rai1tm3Luo
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| Allele Name |
targeted mutation 3
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| Allele Attributes |
Conditional ready (e.g. floxed); Null/Knockout
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| Gene Symbol |
Rai1
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| Gene Name |
retinoic acid induced 1
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| Chromosome |
11
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| MGI Accession ID | show more close |
| Strain of Origin |
129
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| Molecular Note |
A loxP-flanked neomycin-3xpolyA Stop cassette was introduced upstream of the ATG start codon.
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| HUSBANDRY | |
|---|---|
| Suggested Controls |
Wild-type from the colony
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| Breeding Considerations |
Heterozygous mice have reduced fertility and normal viability. Most homozygotes die in utero.
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| Breeding Strategy |
Wild-type x Heterozygote; Heterozygote x Wild-type
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For Research Use Only.
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