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Mouse Models
Site-specific recombinase (SSR) system is widely used in genetically modification, especially the generation for conditional KO and inducible KO mouse models. For making it more efficient and easier, mouse models with special functions have been generated, such as tissue-specifically expressing Cre, inducible expressing Cre, Split-Cre, floxed (target gene were flanked by loxP sites) mouse, et al.
For assisting our global customers making better breakthrough in their research areas, Creative Biogene offers various of mouse models based on site-specific recombinase systems.
- Floxed Mouse: Floxed mouse models provide a way to study gene function in a controlled and tissue-specific manner, allowing researchers to investigate the roles of specific genes in development, physiology, and disease.
- Reporter Mouse: Reporter mouse models generated with SSR technology offer a means to visualize and study gene expression patterns in a tissue-specific or cell-specific manner. They are invaluable tools in deciphering the intricacies of developmental processes and disease mechanisms.
- Inducible Mouse: Inducible mouse models generated with SSR technology are genetically engineered mouse strains that allow for controlled and temporal regulation of gene expression in specific tissues or cell types.
- Recombinase-expressing Mouse: Recombinase-expressing mouse models are genetically modified mouse models that express Cre recombinase tissue-specifically or temporal-specifically.
If you couldn't find the mouse models you need or you are seeking for other model animals, please check out our gene engineering service or just feel free to contact us and get started with our trustable one-stop service.
Our Mouse Models
| 129-Gt(ROSA)26Sortm3(CAG-EGFP/Dsred2)Luo/J (Cat. No.: CEMM-07250032) | Inquiry | |
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These knock-in mice were developed to utilize the mosaic analysis with double markers (MADM) system that allows simultaneous labeling and gene knockout in clones of somatic cells or isolated single cells in vivo. This strain carries the green fluorescent protein, EGFP (G), and the red fluorescent protein, Dsred2 (R), as markers to be used in conjunction with strains carrying the reciprocal chimeric marker genes (MADM-RG).
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| B6.129-Gt(ROSA)26Sortm1(CAG-EGFP)Luo/J (Cat. No.: CEMM-07250036) | Inquiry | |
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These knock-in mice were developed to serve as controls for use with the mosaic analysis with double markers (MADM) system that allows simultaneous labeling and gene knockout in clones of somatic cells or isolated single cells in vivo. This strain carries only the green fluorescent protein, EGFP (G).
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| B6N.Cg-Pou3f4tm2(cre)Cren/Mmjax (Cat. No.: CEMM-07251046) | Inquiry | |
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Pou3f4 knock-in/knock-out mice contain a Cre recombinase that replaces the Pou3f4 (POU domain, class 3, transcription factor 4) coding region. Females homozygous for the mutation and males hemizygous for the X-linked mutation are deaf due to the failure of auditory spiral ganglion neuron radial bundle fasciculation and synapse formation in the cochlea.
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| B6.129(SJL)-Nrp1tm2Ddg/J (Cat. No.: CEMM-07250023) | Inquiry | |
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These mice possess loxP sites flanking exon 2 of the neuropilin 1 (Nrp1) gene and have applications in studies related to cardiovascular and neural system development.
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| B6.129-Sema3ftm1.1Ddg/J (Cat. No.: CEMM-07250024) | Inquiry | |
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These floxed mutant mice possess loxP sites flanking exon 1 of the Sema3f gene. This strain may be useful for generating conditional mutations in applications related to neurobiology research.
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| 129-Gt(ROSA)26Sortm1(CAG-EGFP)Luo/J (Cat. No.: CEMM-07250033) | Inquiry | |
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These knock-in mice were developed to serve as controls for use with the mosaic analysis with double markers (MADM) system that allows simultaneous labeling and gene knockout in clones of somatic cells or isolated single cells in vivo. This strain carries only the green fluorescent protein, EGFP (G).
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| B6.129X1-Gt(ROSA)26Sortm1(EYFP)Cos/J (Cat. No.: CEMM-07250043) | Inquiry | |
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These R26-stop-EYFP mutant mice have a loxP-flanked STOP sequence followed by the Enhanced Yellow Fluorescent Protein gene (EYFP) inserted into the Gt(ROSA)26Sor locus. When bred to mice expressing Cre recombinase, the STOP sequence is deleted and EYFP expression is observed in the cre-expressing tissue(s) of the double mutant offspring. These mutant mice may be useful in monitoring the Cre expression in living tissues, and tracing the lineage of such cells in embryos, young, and adult mice at desired time points.
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| STOCK Gt(ROSA)26Sortm4(ACTB-tdTomato, -EGFP)Luo/J (Cat. No.: CEMM-07250064) | Inquiry | |
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mT/mG, with mT/mG directed to cell membrane and nT/nG directed to nuclei.
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| B6;129S4-Tcf3tm4Zhu/J (Cat. No.: CEMM-07250102) | Inquiry | |
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This Tcfe2a, transcription factor E2a, targeted mutation strain may be useful in generating conditional mutations for studying B and T cell development and for other immunological applications.
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| B6;129S-Gt(ROSA)26Sortm1.1Ksvo/J (Cat. No.: CEMM-07250491) | Inquiry | |
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R26 LSL H2B mCherry (Rosa26-CAG-LSL-H2B-mCherry) mutant mice have a loxP-flanked STOP sequence followed by an H2B-mCherry fusion protein inserted into the Gt(ROSA)26Sor locus. Cre inducible, nuclear expression of the mCherry protein allows the monitoring of Cre activity in living tissues and makes possible lineage tracing of such cells in embryos, young and adult mice at desired time points. While designed to have the floxed-STOP sequence preventing widespread expression of mCherry in the absence of Cre recombinase, low levels of mCherry expression are detectable prior to introduction of Cre recombinase. Importantly, after exposure to Cre recombinase, the mCherry expression levels in the nucleus have been shown to be significantly greater than those baseline levels (e.g., when bred to the strong germline Cre expressing Sox2-Cre mouse line). As such, it is recommended that researchers include Cre-negative R26 LSL H2B mCherry controls to establish the baseline mCherry levels in their experiments.
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For Research Use Only.