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Mouse Models
Site-specific recombinase (SSR) system is widely used in genetically modification, especially the generation for conditional KO and inducible KO mouse models. For making it more efficient and easier, mouse models with special functions have been generated, such as tissue-specifically expressing Cre, inducible expressing Cre, Split-Cre, floxed (target gene were flanked by loxP sites) mouse, et al.
For assisting our global customers making better breakthrough in their research areas, Creative Biogene offers various of mouse models based on site-specific recombinase systems.
- Floxed Mouse: Floxed mouse models provide a way to study gene function in a controlled and tissue-specific manner, allowing researchers to investigate the roles of specific genes in development, physiology, and disease.
- Reporter Mouse: Reporter mouse models generated with SSR technology offer a means to visualize and study gene expression patterns in a tissue-specific or cell-specific manner. They are invaluable tools in deciphering the intricacies of developmental processes and disease mechanisms.
- Inducible Mouse: Inducible mouse models generated with SSR technology are genetically engineered mouse strains that allow for controlled and temporal regulation of gene expression in specific tissues or cell types.
- Recombinase-expressing Mouse: Recombinase-expressing mouse models are genetically modified mouse models that express Cre recombinase tissue-specifically or temporal-specifically.
If you couldn't find the mouse models you need or you are seeking for other model animals, please check out our gene engineering service or just feel free to contact us and get started with our trustable one-stop service.
Our Mouse Models
| STOCK Igs6tm1.1(ACTB-tdTomato, -EFGP)Luo/J (Cat. No.: CEMM-07250453) | Inquiry | |
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The MADM-12TG (Igs6TG) allele has the CMV enhancer/chicken beta-actin core promoter, the N-terminal portion of tdTomato, a beta-globin intronic sequence (containing an frt site and loxP site), and the C-terminal portion of mut4-EGFP all inserted into the Igs6 locus on chromosome 12 (~1.71 cM; ~16 kbp downstream of exon 1 of the Rab10 gene). These MADM-12TG mutants are designed for MADM (mosaic analysis with double markers), and must be crossed to MADM-12GT mice harboring a reciprocal mutation at the same locus. This MADM system allows Cre recombinase-induced fluorescent labeling of daughter cells to ascertain lineal relationships and pleiotropic gene function in multicellular organisms. These mice may also be useful in studies of cell differentiation, mitosis, and imprinting.
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| B6.Cg-Uba6tm1Whpr/J (Cat. No.: CEMM-07250456) | Inquiry | |
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These Uba6flox/flox mutant mice possess loxP sites flanking exons 16-17 of the targeted gene. This strain may be useful for studying the regulation of protein homeostasis during development.
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| 129S-H3f3atm1.1Mnn/J (Cat. No.: CEMM-07250459) | Inquiry | |
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These H3f3ac/c mutant mice possess loxP sites flanking a wildtype H3 histone isoform 3 (H3.3) coding sequence and STOP sequence. When bred to mice expressing cre-recombinase, removal of the floxed sequence results in YFP expression. This strain may be useful for studying the role of histone H3.3 during development.
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| 129S-H3f3btm1.1Mnn/J (Cat. No.: CEMM-07250460) | Inquiry | |
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These H3f3bc/c mutant mice possess loxP sites flanking a wildtype H3 histone isoform 3 (H3.3) coding sequence and STOP sequence. When bred to mice expressing cre-recombinase, removal of the floxed sequence results in CFP expression. This strain may be useful for studying the role of histone H3.3 during development.
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| B6;129-Zic3tm2.1Jwb/J (Cat. No.: CEMM-07250492) | Inquiry | |
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These floxed mutant mice possess loxP sites flanking exon 1 of the X-linked Zic3 gene and may be useful in applications related to the study of embryonic development.
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| STOCK Tfap2atm2Will/J (Cat. No.: CEMM-07250496) | Inquiry | |
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Floxed-AP-2alpha mutant mice possess loxP sites flanking exons 5-6 of the transcription factor AP-2, alpha (Tfap2a) gene. This strain may be useful for studying the developing neural tube.
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| STOCK Sp8tm2Smb/J (Cat. No.: CEMM-07250498) | Inquiry | |
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These floxed mutant mice possess loxP sites flanking the Sp8 coding region. They may be useful in applications related to the study of olfactory neurogenesis, and limb and craniofacial development.
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| STOCK Vapbtm1.2Ics/J (Cat. No.: CEMM-07250510) | Inquiry | |
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These Vspb-/- mice may be useful for studying risk factors for motor neuron diseases such as amyotrophic lateral sclerosis (ALS).
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| STOCK Nlgn1tm1Sud/J (Cat. No.: CEMM-07250511) | Inquiry | |
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These Nlgn1flox mice may be useful for generating tissue specific deletions of Neuroligin 1.
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| STOCK Dact1tm1.2Bnrc/J (Cat. No.: CEMM-07250512) | Inquiry | |
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These Dact1flox mice may be useful for studying embryonic and neuronal development.
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For Research Use Only.