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Mouse Models
Site-specific recombinase (SSR) system is widely used in genetically modification, especially the generation for conditional KO and inducible KO mouse models. For making it more efficient and easier, mouse models with special functions have been generated, such as tissue-specifically expressing Cre, inducible expressing Cre, Split-Cre, floxed (target gene were flanked by loxP sites) mouse, et al.
For assisting our global customers making better breakthrough in their research areas, Creative Biogene offers various of mouse models based on site-specific recombinase systems.
- Floxed Mouse: Floxed mouse models provide a way to study gene function in a controlled and tissue-specific manner, allowing researchers to investigate the roles of specific genes in development, physiology, and disease.
- Reporter Mouse: Reporter mouse models generated with SSR technology offer a means to visualize and study gene expression patterns in a tissue-specific or cell-specific manner. They are invaluable tools in deciphering the intricacies of developmental processes and disease mechanisms.
- Inducible Mouse: Inducible mouse models generated with SSR technology are genetically engineered mouse strains that allow for controlled and temporal regulation of gene expression in specific tissues or cell types.
- Recombinase-expressing Mouse: Recombinase-expressing mouse models are genetically modified mouse models that express Cre recombinase tissue-specifically or temporal-specifically.
If you couldn't find the mouse models you need or you are seeking for other model animals, please check out our gene engineering service or just feel free to contact us and get started with our trustable one-stop service.
Our Mouse Models
| STOCK Mir7-2tm1Mtm/Mmjax (Cat. No.: CEMM-07250255) | Inquiry | |
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These microRNA 7-2 conditional mutant mice are designed to generate a null allele or a lacZ tagged null allele when combined with Flp or Cre recombinase expressing strains. LacZ expression is observed in embryonic brain and spinal cord. This mutant mouse strain may be useful in studies of microRNA biology.
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| STOCK Mir210tm1Mtm/Mmjax (Cat. No.: CEMM-07250258) | Inquiry | |
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These microRNA 210 conditional mutant mice are designed to generate a null allele or a lacZ tagged null allele when combined with Flp or Cre recombinase expressing strains. LacZ expression is not observed in E11.5 and E18.5 embryos. This mutant mouse strain may be useful in studies of microRNA biology.
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| STOCK Mir339tm1Mtm/Mmjax (Cat. No.: CEMM-07250260) | Inquiry | |
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These microRNA 339 conditional mutant mice are designed to generate a null allele or a lacZ tagged null allele when combined with Flp or Cre recombinase expressing strains. LacZ expression is widespread. This mutant mouse strain may be useful in studies of microRNA biology.
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| STOCK Mir30etm1Mtm/Mmjax (Cat. No.: CEMM-07250267) | Inquiry | |
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These microRNA 30e conditional mutant mice are designed to generate a null allele or a lacZ tagged null allele when combined with Flp or Cre recombinase expressing strains. This mutant mouse strain may be useful in studies of microRNA biology.
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| STOCK Mir188tm1Mtm/Mmjax (Cat. No.: CEMM-07250347) | Inquiry | |
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These microRNA 188 conditional mutant mice are designed to generate a null allele or a lacZ tagged null allele when combined with Flp or Cre recombinase expressing strains. This mutant mouse strain may be useful in studies of microRNA biology.
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| 129S-Gt(ROSA)26Sortm1Sor/J (Cat. No.: CEMM-07250006) | Inquiry | |
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These Gt(ROSA)26Sortm1Sor targeted mutant mice carry a loxP flanked neo cassette upstream of a β-galactosidase (lacZ) sequence. Removal of the neo cassette by cre recombination results in lacZ expression in cre-expressing tissues of the offspring.
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| B6;129-Gt(ROSA)26Sortm1Sho/J (Cat. No.: CEMM-07250008) | Inquiry | |
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The β-galactosidase-neomycin phosphotransferase fusion gene (βgeo)-trapped reverse orientation splice acceptor βgeo line 26 (ROSA26) locus was modified by gene targeting such that βgeo is expressed only after Cre-mediated excision of loxP-flanked DNA sequences. These mice may prove useful in the study of cell fate and cell migration during embryogenesis through recombinase-activated tagging.
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| STOCK Gt(ROSA)26Sortm1(Smo/EYFP)Amc/J (Cat. No.: CEMM-07250022) | Inquiry | |
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When these mice are used in conjunction with a Cre recombinase-expressing strain, successful Cre-mediated excision results in the constitutive expression of the Smo/EYFP fusion gene (monitored by using EYFP-specific fluorescence protocols) and unrestrained Hedgehog signaling in Cre-expressing tissues. As examples, this strain may be useful in studies of tumorigenic potential in the hedgehog pathway, progenitor cell involvement in the development of medulloblastomas, craniofacial development, thalamic development, and of oligodendrocyte maturation and CNS myelination when used in combination with specific cre-expressing strains.
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| B6.129-Gt(ROSA)26Sortm2(CAG-Dsred2/EGFP)Luo/J (Cat. No.: CEMM-07250038) | Inquiry | |
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These knock-in mice were developed to utilize the mosaic analysis with double markers (MADM) system that allows simultaneous labeling and gene knockout in clones of somatic cells or isolated single cells in vivo. This strain carries the red fluorescent protein, Dsred2 (R) and the green fluorescent protein, EGFP (G) as markers to be used in conjunction with strains carrying the reciprocal chimeric marker genes (MADM-GR).
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| B6.SJL-Slc6a3tm1.1(cre)Bkmn/J (Cat. No.: CEMM-07250056) | Inquiry | |
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DATIREScre knock-in mice have Cre recombinase expression directed to dopaminergic neurons, without disrupting endogenous dopamine transporter expression. These mice may be useful for studying gene function in dopaminergic neurons, such as drug addiction, Parkinson's disease and Attention Deficit-Hyperactivity Disorder (ADHD).
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For Research Use Only.