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Mouse Models
Site-specific recombinase (SSR) system is widely used in genetically modification, especially the generation for conditional KO and inducible KO mouse models. For making it more efficient and easier, mouse models with special functions have been generated, such as tissue-specifically expressing Cre, inducible expressing Cre, Split-Cre, floxed (target gene were flanked by loxP sites) mouse, et al.
For assisting our global customers making better breakthrough in their research areas, Creative Biogene offers various of mouse models based on site-specific recombinase systems.
- Floxed Mouse: Floxed mouse models provide a way to study gene function in a controlled and tissue-specific manner, allowing researchers to investigate the roles of specific genes in development, physiology, and disease.
- Reporter Mouse: Reporter mouse models generated with SSR technology offer a means to visualize and study gene expression patterns in a tissue-specific or cell-specific manner. They are invaluable tools in deciphering the intricacies of developmental processes and disease mechanisms.
- Inducible Mouse: Inducible mouse models generated with SSR technology are genetically engineered mouse strains that allow for controlled and temporal regulation of gene expression in specific tissues or cell types.
- Recombinase-expressing Mouse: Recombinase-expressing mouse models are genetically modified mouse models that express Cre recombinase tissue-specifically or temporal-specifically.
If you couldn't find the mouse models you need or you are seeking for other model animals, please check out our gene engineering service or just feel free to contact us and get started with our trustable one-stop service.
Our Mouse Models
| C57BL/6J-Tg(CAG-lacZ, -FUS*R521G, -EGFP)673Gyu/J (Cat. No.: CEMM-07250649) | Inquiry | |
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The CAG-Z-FUSR521G-IRES-EGFP transgenic line 673 [or CAG-Z-FUSR521G (673)] has widespread expression of lacZ, that is replaced by expression of the human fused in sarcoma R521G mutant isoform (huFUSR521G) and EGFP fluorescence following exposure to Cre recombinase. The Cre recombinase-inducible expression of huFUSR521G, along with similarly designed transgenic mice harboring the human wildtype FUS, is useful in studying FUS-linked juvenile amyotrophic lateral sclerosis (ALS; Lou Gehrig's Disease), and the neurodegenerative disorder frontotemporal lobar degeneration (FTLD).
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| STOCK Gt(ROSA)26Sortm2(EGFP/cre)Alj/J (Cat. No.: CEMM-07250409) | Inquiry | |
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These R26MASTR mice express an eGFPcre fusion protein following FLP-mediated recombination, allowing simultaneous eGFP-labeling and cre-mediated deletion of floxed alleles within the same mutant cells.
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| B6.Cg-Gt(ROSA)26Sortm38(CAG-GCaMP3)Hze/J (Cat. No.: CEMM-07250711) | Inquiry | |
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Ai38 mice express the fluorescent calcium indicator protein GCaMP3 after exposure to Cre recombinase. Following subsequent calcium binding (such as neuronal activation), bright EGFP fluorescence is observed.
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| B6(C)-Tg(CAG-mCherry, -GAL4)769Gsn/J (Cat. No.: CEMM-07250338) | Inquiry | |
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These transgenic mice carry both an mCherry fluorescent gene flanked by loxP sites and the yeast transcription activator protein GAL4 under the control of a cytomegalovirus enhancer/beta actin promoter (CAG). This strain may be effectively used as a component of the GAL4-UAS (Upstream Activation Sequence) system to activate gene transcription.
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| B6(C)-Tg(CAG-mCherry, -GAL4)774Gsn/J (Cat. No.: CEMM-07250339) | Inquiry | |
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These transgenic mice carry both an mCherry fluorescent gene flanked by loxP sites and the yeast transcription activator protein GAL4 under the control of a cytomegalovirus enhancer/beta actin promoter (CAG). This strain may be effectively used as a component of the GAL4-UAS (Upstream Activation Sequence) system to activate gene transcription.
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| B6.Cg-Gt(ROSA)26Sortm40.1(CAG-aop3/EGFP)Hze/J (Cat. No.: CEMM-07250437) | Inquiry | |
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These Ai40D mice conditionally express an improved Archaerhodopsin-3/EGFP fusion protein (ArchT-EGFP) from the endogenous Gt(ROSA)26Sor locus. Expression is enhanced by the presence of a CAG promoter. Following Cre-mediated removal of the floxed-STOP cassette, ArchT-EGFP expression is observed in the cre-expressing cells. Subsequent illumination of these cells with yellow-green light (~575 nm) leads to reversible photoinhibition of action potential firing/neural activity in these cells. These Ai40D mice are useful for optogenetic studies to express an inhibitory opsin that effectively silences the activity of cortical neurons (and perhaps other excitable cell types such as muscle cells and immune cells). ArchT has greater than 3-fold improvement in light sensitivity compared to Arch, equating to greater than 200% increase in brain tissue volume addressed by a typical single optical fiber.
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| NOD.129(Cg)-Gt(ROSA)26Sortm4(ACTB-tdTomato, -EGFP)Luo/YgchJ (Cat. No.: CEMM-07251113) | Inquiry | |
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mT/mG, with mT/mG directed to cell membrane and nT/nG directed to nuclei.
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| STOCK Mir688tm1Mtm/Mmjax (Cat. No.: CEMM-07250276) | Inquiry | |
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These microRNA 688 conditional mutant mice are designed to generate a null allele or a lacZ tagged null allele when combined with Flp or Cre recombinase expressing strains. LacZ expression is observed in brain. This mutant mouse strain may be useful in studies of microRNA biology.
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| STOCK Mirc6tm1Mtm/Mmjax (Cat. No.: CEMM-07250277) | Inquiry | |
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These microRNA cluster 6 (miR-654/miR-376b) conditional mutant mice are designed to generate a null allele or a lacZ tagged null allele when combined with Flp or Cre recombinase expressing strains. LacZ expression is observed in embryonic brain and spinal cord. This mutant mouse strain may be useful in studies of microRNA biology.
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| STOCK Mir150tm1Mtm/Mmjax (Cat. No.: CEMM-07250278) | Inquiry | |
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These microRNA 150 conditional mutant mice are designed to generate a null allele or a lacZ tagged null allele when combined with Flp or Cre recombinase expressing strains. This mutant mouse strain may be useful in studies of microRNA biology.
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For Research Use Only.