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B6J.129S6(129S4)-Slc17a6tm1Lowl/RujfJ

Cat. No.: CEMM-07250958

Common Name: Vglut2flox
Exon 2 of the mouse Slc17a6 (sodium-dependant inorganic phosphate cotransporter, member 6; also known as Vglut2) gene is flanked by loxP sites in these Vglut2flox mutant mice. Cre recombinase-mediated excision of the floxed exon generates a knock-out allele. These mice may be useful for studying the effect of transport, packaging, and release of glutamate from ventromedial hypothalamic (VMH) neurons on hypoglycemia. has been backcrossed to C57BL/6J for more than 10 generations by the donating laboratory.
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Status Live Mouse
Frozen Embryo
Age 4 weeks
12 weeks
Customized Age
Sex Male
Female
GENETICS
Allele Symbol
Slc17a6tm1Lowl
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Allele Name
targeted mutation 1
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Allele Attributes
Conditional ready (e.g. floxed); No functional change
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Gene Symbol
Slc17a6
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Gene Name
solute carrier family 17 (sodium-dependent inorganic phosphate cotransporter)
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Chromosome
7
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MGI Accession ID
3771177
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Strain of Origin
129S6/SvEvTac
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Molecular Note
Lox P sites were inserted upstream and downstream of exon 2. A neo cassette used for selection purposes was removed by flp-mediated recombination.
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HUSBANDRY
Suggested Controls
C57BL/6J Wild-type from the colony
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Breeding Considerations
Heterozygotes and homozygotes are viable and fertile.
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Breeding Strategy
Homozygote x Homozygote
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Coat Color
The coat color is black.
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For Research Use Only.
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