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B6(Cg)-Sncatm1.1Vlb/J
Cat. No.: CEMM-07250571
Common Name: SNCAflox delta neo
These floxed mutant mice possess loxP sites flanking the first coding exon of the Snca gene. This strain may be useful for generating conditional mutations in applications related to neurodegenerative synucleinopathies, such as Parkinson's disease and multiple system atrophy.
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| Status | Live Mouse Frozen Embryo |
| Age | 4 weeks 12 weeks Customized Age |
| Sex | Male Female |
| GENETICS | |
|---|---|
| Allele Symbol |
Sncatm1.1Vlb
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| Allele Name |
targeted mutation 1.1
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| Allele Attributes |
Conditional ready (e.g. floxed); No functional change
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| Gene Symbol |
Snca
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| Gene Name |
synuclein
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| Chromosome |
6
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| MGI Accession ID | show more close |
| Strain of Origin |
C57BL/6N-Atm1Brd
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| Molecular Note |
A targeting vector containing a FRT site-flanked neo cassette and a loxP site was inserted downstream of exon 2 (the first coding exon) of the targeted gene, and another loxP site was inserted upstream of exon 2. Flp-mediated recombination removed the FRT flanked neo cassette leaving exon 2 floxed.
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| HUSBANDRY | |
|---|---|
| Suggested Controls |
C57BL/6J
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| Breeding Considerations |
When maintaining a live colony, these mice can be bred as homozygotes.
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For Research Use Only.
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