Online Inquiry
B6.Cg-Pou4f2tm1(cre)Bnt/SjJ
Cat. No.: CEMM-07250870
Common Name: Pou4f2Cre
This knock-in/knock-out strain, backcrossed to C57BL/6J from the original mixed genetic background (see), expresses cre recombinase from the Pou4f2 promoter. In the original line, cre expression is observed in the retina, brain, intestines, heart, and gonads.
Inquiry
| Status | Live Mouse Frozen Embryo |
| Age | 4 weeks 12 weeks Customized Age |
| Sex | Male Female |
| GENETICS | |
|---|---|
| Allele Symbol |
Pou4f2tm1(cre)Bnt
show more
close
|
| Allele Name |
targeted mutation 1
show more
close
|
| Allele Attributes |
Recombinase-expressing
show more
close
|
| Gene Symbol |
Pou4f2
show more
close
|
| Gene Name |
POU domain
show more
close
|
| Chromosome |
8
show more
close
|
| Expressed Genes |
Cre, Cre recombinase, bacteriophage P1
show more
close
|
| MGI Accession ID | show more close |
| Site of Expression |
When Pou4f2Cre mice are crossed with animals carrying a loxP-flanked sequence of interest, Cre-mediated excision of the floxed region occurs in the retina, brain (optic tract, hippocampus, cortex), intestines, heart, and gonads (ovary and testes).
show more
close
|
| Strain of Origin |
Not Specified
show more
close
|
| Molecular Note |
An internal ribosome entry site (IRES)-Cre was fused to exon 1, disrupting the mouse Pou4f2 gene. A neomcyin cassette, in reverse transcriptional orientation, was placed downstream.
show more
close
|
| HUSBANDRY | |
|---|---|
| Suggested Controls |
C57BL/6J Wild-type from the colony
show more
close
|
| Breeding Considerations |
Heterozygotes are viable and fertile. Homozygous viability/fertility of the C57BL/6J-backcrossed line has not been tested (January, 2018).
show more
close
|
| Breeding Strategy |
Wild-type x Heterozygote; Heterozygote x Wild-type
show more
close
|
For Research Use Only.
Related Products