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B6.Cg-Hsd11b2tm1.1(cre/GFP)Rpa/J
Cat. No.: CEMM-07250812
Common Name: Hsd11b2Cre:GFP
These targeted mutant mice express IRES-Cre from the mouse Hsd11b2 promoter in Hs11b2-expressing cells of the nucleus tractus solitarius (NTS).
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| Status | Live Mouse Frozen Embryo |
| Age | 4 weeks 12 weeks Customized Age |
| Sex | Male Female |
| GENETICS | |
|---|---|
| Allele Symbol |
Hsd11b2tm1.1(cre/GFP)Rpa
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| Allele Name |
targeted mutation 1.1
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| Allele Attributes |
Recombinase-expressing; Reporter
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| Gene Symbol |
Hsd11b2
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| Gene Name |
hydroxysteroid 11-beta dehydrogenase 2
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| Chromosome |
8
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| Expressed Genes |
GFP/Cre, Green Fluorescent Protein/Cre recombinase fusion protein
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| MGI Accession ID | show more close |
| Site of Expression |
IRES-Cre is expressed in Hs11b2-expressing cells of the nucleus tractus solitarius.
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| Strain of Origin |
(129S6/SvEvTac x C57BL/6NCrl)F1
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| Molecular Note |
IRES-Myc tag-nuclear localization signal (NLS)-Cre-GFP-FRT neomycin-FRT were introduced just after the termination codon of the mouse Hsd11b2 gene via homologous recombination. The neomycin cassette was excised through crosses with animals broadly expressing Flp recombinase.
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| HUSBANDRY | |
|---|---|
| Suggested Controls |
C57BL/6J Wild-type from the colony
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| Breeding Considerations |
Heterozygotes are viable and fertile. Homozygotes are viable, but fertility has not been checked.
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| Breeding Strategy |
Wild-type x Heterozygote; Heterozygote x Wild-type
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For Research Use Only.
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