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129S-Pafah1b1tm2Awb/J

Cat. No.: CEMM-07250092

These mice possess loxP sites flanking exons 3 through 6 of the targeted gene. When these mutant mice are bred to mice that express Cre recombinase, resulting offspring will have exons 3 through 6 deleted in the cre-expressing tissue(s). This mutant mouse strain may be useful in studies of neurological development.
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Status Live Mouse
Frozen Embryo
Age 4 weeks
12 weeks
Customized Age
Sex Male
Female
GENETICS
Allele Symbol
Pafah1b1tm2Awb
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Allele Name
targeted mutation 2
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Allele Attributes
Conditional ready (e.g. floxed); Hypomorph
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Gene Symbol
Pafah1b1
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Gene Name
platelet-activating factor acetylhydrolase
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Chromosome
11
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MGI Accession ID
2384060
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Strain of Origin
129S6/SvEvTac
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Molecular Note
A floxed PGK-neo cassette was inserted into intron 2 and a third loxP site was introduced into intron 6 via homologous recombination. This allele is hypomorphic, because of disruption of transcription or splicing by the insertion of a phosphoglycerate kinase neomycin cassette from the targeting vector into the second intron.
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HUSBANDRY
Suggested Controls
129S1/SvImJ
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Breeding Considerations
When maintaining a live colony, heterozygous mice may be bred together, to wildtype mice from the colony or to 129S1/SvImJ inbred mice. Alternatively, homozygotes may be bred together.
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For Research Use Only.
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