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129-Braftm1Sva/J
Cat. No.: CEMM-07250047
Common Name: B-raff
These floxed mutant mice possess loxP sites flanking exon 12 of the Braf gene. This strain may be useful for generating conditional mutations in neurological studies.
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| Status | Live Mouse Frozen Embryo |
| Age | 4 weeks 12 weeks Customized Age |
| Sex | Male Female |
| GENETICS | |
|---|---|
| Allele Symbol |
Braftm1Sva
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| Allele Name |
targeted mutation 1
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| Allele Attributes |
Conditional ready (e.g. floxed); No functional change
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| Gene Symbol |
Braf
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| Gene Name |
Braf transforming gene
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| Chromosome |
6
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| MGI Accession ID | show more close |
| Strain of Origin |
(129X1/SvJ x 129S1/Sv)F1-Kitl+
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| Molecular Note |
A targeting construct was designed to flank exon 12 (exon 9 according to nomenclature in J:29234) with loxP sites. This exon is the first to encode the kinase domain. Its excision would result in a frame shift in the ORF, resulting in a null mutation. Western blot confirmed that insertion of the loxP sites did not affect protein expression levels.
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| HUSBANDRY | |
|---|---|
| Suggested Controls |
129T2/SvEmsJ
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| Breeding Considerations |
When maintaining a live colony, heterozygous or homozygous mice can be bred.
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For Research Use Only.
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