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Mouse Models
Site-specific recombinase (SSR) system is widely used in genetically modification, especially the generation for conditional KO and inducible KO mouse models. For making it more efficient and easier, mouse models with special functions have been generated, such as tissue-specifically expressing Cre, inducible expressing Cre, Split-Cre, floxed (target gene were flanked by loxP sites) mouse, et al.
For assisting our global customers making better breakthrough in their research areas, Creative Biogene offers various of mouse models based on site-specific recombinase systems.
- Floxed Mouse: Floxed mouse models provide a way to study gene function in a controlled and tissue-specific manner, allowing researchers to investigate the roles of specific genes in development, physiology, and disease.
- Reporter Mouse: Reporter mouse models generated with SSR technology offer a means to visualize and study gene expression patterns in a tissue-specific or cell-specific manner. They are invaluable tools in deciphering the intricacies of developmental processes and disease mechanisms.
- Inducible Mouse: Inducible mouse models generated with SSR technology are genetically engineered mouse strains that allow for controlled and temporal regulation of gene expression in specific tissues or cell types.
- Recombinase-expressing Mouse: Recombinase-expressing mouse models are genetically modified mouse models that express Cre recombinase tissue-specifically or temporal-specifically.
If you couldn't find the mouse models you need or you are seeking for other model animals, please check out our gene engineering service or just feel free to contact us and get started with our trustable one-stop service.
Our Mouse Models
| B6;129S-Tac2tm1.1(cre)Hze/J (Cat. No.: CEMM-07250463) | Inquiry | |
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Tac2-IRES2-Cre-D mice (also called Tac2-IRES2-Cre-Δ or Tac2-IRES2-Cre-Δneo/hygro) have both endogenous gene and Cre recombinase expression directed to Tac2-expressing cells by the endogenous promoter/enhancer elements of the tachykinin 2 locus. Tac2 encodes neurokinin B (NKB), a neuromodulator that plays a role in pain modulation. These mice may be useful to generate conditional mutations for studying gain or loss of function and/or mapping in the brain.
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| B6;129S-Snap25tm2.1(cre)Hze/J (Cat. No.: CEMM-07250502) | Inquiry | |
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Snap25-IRES2-Cre-D knock-in mice have widespread Cre recombinase expression directed throughout the brain, without disrupting endogenous synaptosomal-associated protein 25 expression. These mice may be useful for studying t-SNARE proteins and synaptic vesicle/plasma membrane fusion.
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| B6;129S-Slc17a7tm1.1(cre)Hze/J (Cat. No.: CEMM-07250504) | Inquiry | |
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Slc17a7-IRES2-Cre-D knock-in mice have Cre recombinase expression directed to Vglut1-expressing cells, without disrupting endogenous vesicular glutamate transporter 1 expression. These mice may be useful for studying glutamatergic synaptic vesicle trafficking and vesicle-bound, sodium-dependent phosphate transportation.
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| B6.Cg-Erbb4tm1.1(cre/ERT2)Aibs/J (Cat. No.: CEMM-07250219) | Inquiry | |
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Erbb4-2A-CreERT2-D mice have both endogenous gene and CreERT2 fusion protein expression directed to Erbb4-expressing cells by the endogenous promoter/enhancer regions of the Erbb4 locus (v-erb-a erythroblastic leukemia viral oncogene homolog 4 (avian)). When Erbb4-2A-CreERT2-D mice are bred with mice containing loxP-flanked sequences, tamoxifen-inducible Cre-mediated recombination will result in deletion of the floxed sequences in the Erbb4-expressing cells of the double mutant offspring.
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| B6.Cg-Gt(ROSA)26Sortm27.1(CAG-COP4*H134R/tdTomato)Hze/J (Cat. No.: CEMM-07250226) | Inquiry | |
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Ai27D mice express an improved channelrhodopsin-2/tdTomato fusion protein following exposure to Cre recombinase. These mice can be used in optogenetic studies for rapid in vivo activation of excitable cells by illumination with blue light (450-490 nm).
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| B6;129S-Gt(ROSA)26Sortm34.1(CAG-Syp/tdTomato)Hze/J (Cat. No.: CEMM-07250228) | Inquiry | |
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Ai34D mice harbor a knock-in mutation of the Gt(ROSA)26Sor locus with a loxP-flanked STOP cassette preventing transcription of a CAG promoter-driven Synaptophysin-tdTomato fusion gene. Following Cre-mediated removal of the STOP cassette, Synaptophysin-tdTomato expression is observed at synaptic termini in brain regions.
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| B6;129S-Rorbtm1.1(cre)Hze/J (Cat. No.: CEMM-07250503) | Inquiry | |
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Rorb-IRES2-Cre-D knock-in mice have Cre recombinase expression directed to Rorb-expressing cells, without disrupting endogenous RAR-related orphan receptor beta expression. These mice may be useful for studying this nuclear hormone receptor/DNA-binding protein in hormone-responsive gene expression and behavior.
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| STOCK En1tm2(cre)Wrst/J (Cat. No.: CEMM-07250082) | Inquiry | |
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These En1Cki (or En1Cre) mutant mice harbor a Cre recombinase (cre) "knock-in" allele that also abolishes endogenous gene function and may be useful for Cre-lox applications studying engrailed protein function such as deleting genes in spinal cord V1 interneurons, the embryonic mesencephalon and rhombomere 1 by E9, as well as in the ventral ectoderm of the limbs, in a subset of somite cells, and some mesoderm-derived tissues.
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| STOCK En1tm7(cre/ESR1)Alj/J (Cat. No.: CEMM-07250083) | Inquiry | |
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En1-CreERT1 mutant mice harbor the Cre-ERT1 fusion gene under control of the endogenous engrailed 1 locus. When En1-CreERT1 mice are bred with mice containing a loxP-flanked sequence of interest, tamoxifen-inducible, Cre-mediated recombination will result in deletion of the flanked sequences in En1-expressing tissues (including the mesencephalon and rhombomere 1, as well as the developing cerebellum, dermis, and limbs).
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| B6;129-Ubbtm1Rrk/J (Cat. No.: CEMM-07250125) | Inquiry | |
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These mice have a GFP-puror fusion protein "knock-in" mutation of the Ubb (ubiquitin B) gene that also abolishes endogenous gene function and may be useful for fluorescent labeling and/or Ubb-deficiency in studying gametogenesis, meiosis, neuron development and survival, neuropathogenic disease, and adult-onset obesity linked to selective hypothalamic neurodegeneration.
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For Research Use Only.