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Mouse Models
Site-specific recombinase (SSR) system is widely used in genetically modification, especially the generation for conditional KO and inducible KO mouse models. For making it more efficient and easier, mouse models with special functions have been generated, such as tissue-specifically expressing Cre, inducible expressing Cre, Split-Cre, floxed (target gene were flanked by loxP sites) mouse, et al.
For assisting our global customers making better breakthrough in their research areas, Creative Biogene offers various of mouse models based on site-specific recombinase systems.
- Floxed Mouse: Floxed mouse models provide a way to study gene function in a controlled and tissue-specific manner, allowing researchers to investigate the roles of specific genes in development, physiology, and disease.
- Reporter Mouse: Reporter mouse models generated with SSR technology offer a means to visualize and study gene expression patterns in a tissue-specific or cell-specific manner. They are invaluable tools in deciphering the intricacies of developmental processes and disease mechanisms.
- Inducible Mouse: Inducible mouse models generated with SSR technology are genetically engineered mouse strains that allow for controlled and temporal regulation of gene expression in specific tissues or cell types.
- Recombinase-expressing Mouse: Recombinase-expressing mouse models are genetically modified mouse models that express Cre recombinase tissue-specifically or temporal-specifically.
If you couldn't find the mouse models you need or you are seeking for other model animals, please check out our gene engineering service or just feel free to contact us and get started with our trustable one-stop service.
Our Mouse Models
| B6.Cg-Igs7tm169.1(tetO-GFP*/TPTE2*, CAG-tTA2)Hze/J (Cat. No.: CEMM-07250877) | Inquiry | |
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Ai169(TIT2L-ASAP2s-ICL-tTA2)-D (or Ai169D) mice are a Cre/Tet-dependent, voltage-sensitive, fluorescent line - created by targeted insertion at the Igs7 locus (TIGRE; an intergenic region on mouse chromosome 9 that allows reporter expression to be tightly regulated). Exposure to Cre recombinase removes both STOP cassettes - resulting in expression of tTA2 and ASAP2s (green fluorescent voltage indicator with high sensitivity). ASAP2s expression may then be diminished by doxycycline. Ai169D mice may be useful for in vivo imaging of voltage dynamics.
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| B6.Cg-Igs7tm170.1(tetO-GFP*/TPTE2*, CAG-tTA2)Hze/J (Cat. No.: CEMM-07250878) | Inquiry | |
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Ai170(TIT2L-ASAP2s-Kv-ICL-tTA2)-D (or Ai170D) mice are a Cre/Tet-dependent, voltage-sensitive, fluorescent line for neuronal soma and proximal dendrites - created by targeted insertion at the Igs7 locus (TIGRE; an intergenic region on mouse chromosome 9 that allows reporter expression to be tightly regulated). Exposure to Cre recombinase removes both STOP cassettes - resulting in expression of tTA2 and ASAP2s-Kv (highly-sensitive green fluorescent voltage indicator with Kv2.1-tag). ASAP2s-Kv expression may then be diminished by doxycycline. Ai170D mice may be useful for in vivo imaging of voltage dynamics in soma and proximal dendrites.
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| C57BL/6N-Tg(Npy-EGFP/RNAi:Gad1)1Mirn/J (Cat. No.: CEMM-07250680) | Inquiry | |
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The Npy-eGFP-miGAD67 line 1 BAC transgenic mouse line is a hybrid reporter/miRNA knockdown model where neuropeptide Y interneuronal expression of a synthetic Gad1 miRNA precursor results in Gad1 transcript downregulation (silencing of GAD1 expression) via endogenous miRNA processing mechanisms. These mice may be useful in studying NPY+ GABAergic interneurons in behavioral and molecular processes, as well as cell-type specific GABAergic disturbances in manifestations of schizophrenia.
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| C57BL/6N-Tg(Cck-EGFP/RNAi:Gad1)2Mirn/J (Cat. No.: CEMM-07250681) | Inquiry | |
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The Cck-eGFP-miGAD67 line 2 BAC transgenic mouse line is a hybrid reporter/miRNA knockdown model where cholecystokinin interneuronal expression of a synthetic Gad1 miRNA precursor results in Gad1 transcript downregulation (silencing of GAD1 expression) via endogenous miRNA processing mechanisms. These mice may be useful in studying CCK+ GABAergic interneurons in behavioral and molecular processes, as well as cell-type specific GABAergic disturbances in manifestations of schizophrenia.
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| B6.Cg-Igs7tm133.1(tetO-apx1*)Hze/J (Cat. No.: CEMM-07250784) | Inquiry | |
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Ai133(TITL-ssAPEX2tm)-D (also called Ai133D) mice are a Cre/Tet-dependent, substrate-dependent reporter line - created by targeted insertion of floxed-STOP-APEX2 at the Igs7 locus (TIGRE; an intergenic region on mouse chromosome 9 that allows reporter expression to be tightly regulated). After removal of the floxed-STOP cassette by Cre recombinase, they may be used to generate Tet-Off/Tet-On mutant animals with conditional (inducible/reversible) expression of APEX2 - an engineered peroxidase with improved catalytic efficiency that functions as an electron microscopy tag and a promiscuous labeling enzyme for live-cell proteomics.
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| B6.Cg-Igs7tm136.1(tetO-COP3*/COP4*/EYFP)Hze/J (Cat. No.: CEMM-07250785) | Inquiry | |
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Ai136(TITL-ReaChR-YFP)-D (also called Ai136D) mice are a Cre/Tet-dependent, optogenetic line, created by targeted insertion at the Igs7 locus (TIGRE; an intergenic region on mouse chromosome 9 that allows reporter expression to be tightly regulated). Following Cre-mediated removal of the STOP cassette, they may be used to generate Tet-Off/Tet-On mutant animals with conditional (inducible/reversible) expression of the channelrhodopsin/EYFP fusion protein (ReaChR/EYFP). Subsequent illumination of ReaChR-expressing (EYFP fluorescent) cells with orange-to-red light leads to reversible photostimulation of action potential firing/neural activity in these cells.
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| B6.Cg-Igs7tm139.1(tetO-EGFP, CAG-tdTomato, -tTA2)Hze/J (Cat. No.: CEMM-07250787) | Inquiry | |
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Ai139(TIT2L-GFP-ICL-TPT)-D (also called Ai139D) mice are a Cre-dependent, Tet-controllable dual fluorescent reporter line, created by targeted insertion at the Igs7 locus (TIGRE; an intergenic region on mouse chromosome 9 that allows reporter expression to be tightly regulated). Exposure to Cre recombinase removes both STOP cassettes - resulting in EGFP fluorescence, tdTomato fluorescence and tTA2 expression - and that EGFP expression may be diminished/eliminated by doxycycline.
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| B6;129-Gt(ROSA)26Sortm2(CAG-COP4*C128S*D156A*T159C, -tdTomato)Gfng/J (Cat. No.: CEMM-07250912) | Inquiry | |
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R26-LSL-SOUL-P2A-tdT mice are a Cre-dependent, optogenetic line with a loxP-flanked STOP cassette preventing transcription of a step-function opsin with ultra-high light sensitivity (SOUL; a channelrhodopsin modified to have step function-like properties with extended channel open state and enhanced photocurrent amplitudes) and a tdTomato fluorescent protein. After Cre recombinase exposure, subsequent illumination of SOUL-expressing cells with blue light (~470 nm) leads to stable step in membrane potential (depolarization) in these cells - and the channel can remain in the conducting state for more than 30 minutes, during which time it can be deactivated using orange light (~590 nm).
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| B6;129S6-Igs7tm139(tetO-EGFP, CAG-tdTomato, -tTA2)Hze/J (Cat. No.: CEMM-07250973) | Inquiry | |
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Ai139 (also called Ai139(TIT2L-EGFP-ICL-TPT)) is a Cre-dependent, Tet-controllable dual fluorescent reporter line, created by targeted insertion at the Igs7 locus (TIGRE). Exposure to Cre recombinase removes both STOP cassettes resulting in tTA2 expression, robust EGFP fluorescence and robust tdTomato fluorescence. EGFP expression may be diminished/eliminated by doxycycline.
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| B6(Cg)-Esr1tm1.1(icre)Jako/J (Cat. No.: CEMM-07250863) | Inquiry | |
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Esr1-iCre knock-in/knock-out mice express codon optimized Cre recombinase from the endogenous Esr1 locus. Cre recombinase expression mimics endogenous Esr1 gene expression.
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